Evidence map›Paper›PMID 42817016›Full record

ArticleThe Journal of physiology2026

Slow calcium removal contributes to impaired lusitropic response to β-adrenergic stimulation in HFpEF mice.

Tamzin Zawadzki, Diana S Usai, Sif G Kaad, Katrine H Rasmussen, Mie S Larsen, Jens C B Jacobsen, Morten B Thomsen

Abstract read
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In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tamzin ZawadzkiDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Diana S UsaiDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sif G KaadDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Katrine H RasmussenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mie S LarsenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0009-0001-3549-2207
Jens C B JacobsenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Morten B ThomsenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-2469-6458

Funding

Carlsbergfondet CF19-0067Independent Research Fund Denmark 2034-00073BNovo Nordisk Fonden NNF18OC0032728
6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) accounts for over half of heart failure cases, yet its underlying mechanisms remain incompletely understood and effective therapies are lacking. Diastolic dysfunction, a hallmark of HFpEF, may arise from impaired active myocardial relaxation, but the contribution of intracellular calcium (Ca

Indexed as

Adrenergic beta-AgonistsCalciumHeart FailureAnimalsMaleMiceMice, Inbred C57BLMyocardial ContractionMyocytes, CardiacStroke VolumeAdrenergic beta-AgonistsCalciumDiastolic dysfunctionexcitation–contraction couplinglusitropyventricular myocyteβ‐adrenergic signalling

Identifiers

PMID42817016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.