Evidence map›Paper›PMID 42816885›Full record

ArticleJournal of intensive care2026

Rapid progression of diffuse alveolar damage in ARDS: temporal alignment, composite phenotype, and physiological interpretation.

Weixu Mao, Xuanjun Liu, Wei Liu

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Weixu MaoThe Second Clinical Medical College of Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, China.
Xuanjun LiuDepartment of General Surgery, The Affiliated Yongchuan Hospital of Chongqing Medical University, Yongchuan District, Chongqing, 402160, China.
Wei LiuThe Second Clinical Medical College of Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, China. liuwei980828lw@163.com.ORCID https://orcid.org/0009-0008-5756-6079

Funding

the Basic Research Program of Guizhou Provincial Department of Science and Technology qiankehe jichu [2020]1Y364the National Natural Science Foundation of China 82160952
6 · The paper itself

Abstract

A recent study associated early proliferative or fibrotic diffuse alveolar damage with mortality in acute respiratory distress syndrome. We highlight four interpretive concerns: phenotype status was assigned at biopsy after follow-up began, creating potential immortal-time bias; a single biopsy cannot measure pathological velocity; sparse and imbalanced phase-by-timing cells limit component-specific inference; and concurrent physiological measurements complicate causal interpretation. Until delayed-entry survival and phase-specific sensitivity analyses are reported, the phenotype is better viewed as early advanced-phase histology than evidence of accelerated pathology.

Indexed as

Acute respiratory distress syndromeDiffuse alveolar damageImmortal-time biasLung biopsySurvival analysis

Identifiers

PMID42816885
PMCPMC13625332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.