Evidence map›Paper›PMID 42816875›Full record

ArticleJournal of nanobiotechnology2026

MHY@MO@PPP inhibits ferroptosis positive feedback and delays the acute kidney injury-to-chronic kidney disease transition by remodeling the Fe

Chenhao Li, Chao Zhang, Chuanqi Zhang, Shiyu Duan, Jiali Zhang, Hongyue Wang

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenhao LiDepartment of Nephrology, Lequn Branch, The First Hospital of Jilin University, No. 3302 Jilin Road, Erdao District, Changchun, 130031, Jilin Province, China.
Chao ZhangUltrasound Diagnostic Center, The First Hospital of Jilin University, Changchun, 130031, China.
Chuanqi ZhangDepartment of Nephrology, Lequn Branch, The First Hospital of Jilin University, No. 3302 Jilin Road, Erdao District, Changchun, 130031, Jilin Province, China.
Shiyu DuanDepartment of Nephrology, Lequn Branch, The First Hospital of Jilin University, No. 3302 Jilin Road, Erdao District, Changchun, 130031, Jilin Province, China.
Jiali ZhangDepartment of Nephrology, Lequn Branch, The First Hospital of Jilin University, No. 3302 Jilin Road, Erdao District, Changchun, 130031, Jilin Province, China.
Hongyue WangDepartment of Nephrology, Lequn Branch, The First Hospital of Jilin University, No. 3302 Jilin Road, Erdao District, Changchun, 130031, Jilin Province, China. hongyue@jlu.edu.cn.

Funding

the Natural Science Foundation of Jilin Province No. YDZJ202501ZYTS025
6 · The paper itself

Abstract

AKI-to-CKD progression is shaped by sustained tubular stress, ferroptosis-related iron imbalance, and oxidative injury. To target this process, we developed an MHY1485-loaded molybdenum oxide (MoOx) nanozyme coated with a pH-responsive phenylboronic acid-polyethylene glycol-phenylboronic acid (PBA-PEG-PBA) polymer (MHY@MO@PPP). We tested whether this platform could weaken the ferroptosis-associated injury loop and delay AKI-to-CKD transition through regulation of the Fe

Indexed as

Acute Kidney InjuryFerroptosisMolybdenumPhospholipid Hydroperoxide Glutathione PeroxidaseRenal Insufficiency, ChronicAnimalsBoronic AcidsCell LineHumansIronMaleMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLOxidesPolyethylene GlycolsBoronic AcidsIronMechanistic Target of Rapamycin Complex 1MolybdenumOxidesPhospholipid Hydroperoxide Glutathione PeroxidasePolyethylene GlycolsAcute kidney injury-to-chronic kidney disease transitionFe2+-mTORC1-GPX4 AxisFerroptosisGlutathione peroxidase 4 (GPX4)Mechanistic target of rapamycin complex 1 (mTORC1)Molybdenum Oxide Nanozyme

Identifiers

PMID42816875
PMCPMC13625235

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.