Evidence map›Paper›PMID 42816837›Full record

ArticleBMC psychiatry2026

Neuropsychobiological transdiagnostic risk mechanisms for aggression in mental disorders across the life span.

Ute Habel, Andreas Reif, Sabine Herpertz, Kerstin Konrad, Christine Freitag, Tobias Banaschewski, Thomas Frodl, Catherine Barnes-Scheufler, Lisa Berg, Katja Bertsch and 27 more

Abstract read
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In one paragraph

Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Ute HabelInstitute for Translational Neuroscience and Clinical Psychology, Uniklinik RWTH, Aachen, Aachen, Germany. uhabel@ukaachen.de.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany. reif@med.uni-frankfurt.de.
Sabine HerpertzDepartment of Psychiatry and Psychotherapy, University of Heidelberg, Heidelberg, Germany. sabine.herpertz@uni-heidelberg.de.
Kerstin Konrad, INM-10, Research Center Jülich, Jülich, Germany. kkonrad@ukaachen.de.
Christine FreitagDepartment of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany. c.freitag@em.uni-frankfurt.de.
Tobias BanaschewskiCentral Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. tobias.banaschewski@zi-mannheim.de.
Thomas FrodlDepartment of Psychiatry, Psychotherapy and Psychosomatics, Uniklinik RWTH Aachen, Aachen, Germany. tfrodl@ukaachen.de.
Catherine Barnes-ScheuflerDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Lisa BergDepartment of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Katja BertschDepartment of Psychology I (Biological Psychology, Clinical Psychology, and Psychotherapy), University of Würzburg, Würzburg, Germany.
Natalya Chechko, INM-10, Research Center Jülich, Jülich, Germany.
Andreas G ChiocchettiDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Christine EckerDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Gabriele EndeCentral Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Antonia FritschCentral Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Chiara GramegnaInstitute for Translational Neuroscience and Clinical Psychology, Uniklinik RWTH, Aachen, Aachen, Germany.
Michael HankeINM-7, Research Center Jülich, Jülich, Germany.
Nathalie HolzCentral Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Philippa HüpenInstitute for Translational Neuroscience and Clinical Psychology, Uniklinik RWTH, Aachen, Aachen, Germany.
Ina KuschelDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Klaus MathiakDepartment of Psychiatry, Psychotherapy and Psychosomatics, Uniklinik RWTH Aachen, Aachen, Germany.
Annika MaasInstitute of Medical Psychology and Medical Sociology, Uniklinik RWTH, Aachen, Aachen, Germany.
Andreas Meyer-LindenbergCentral Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Corinne NeukelDepartment of Psychiatry and Psychotherapy, University of Heidelberg, Heidelberg, Germany.
Christian ParetCentral Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Michael PlichtaDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Vanessa ReindlInstitute of Medical Psychology and Medical Sociology, Uniklinik RWTH, Aachen, Aachen, Germany.
Wolfgang RetzInstitute for Forensic Psychology and Psychiatry, Saarland University, Homburg, Germany.
Jaqueline ScharfDepartment of Psychiatry and Psychotherapy, University of Heidelberg, Heidelberg, Germany.
Christian SchmahlCentral Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Henry SchirokDepartment of Psychiatry and Psychotherapy, University of Heidelberg, Heidelberg, Germany.
Heike TostCentral Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Daniel TurnerLeibniz Institute for Resilience Research (LIR), University Medical Center Mainz, Mainz, Germany.
Oliver TüscherLeibniz Institute for Resilience Research (LIR), University Medical Center Mainz, Mainz, Germany.
Lisa WagelsInstitute for Translational Neuroscience and Clinical Psychology, Uniklinik RWTH, Aachen, Aachen, Germany.
Carmen WeidlerInstitute for Translational Neuroscience and Clinical Psychology, Uniklinik RWTH, Aachen, Aachen, Germany.
Jana ZweeringsDepartment of Psychiatry, Psychotherapy and Psychosomatics, Uniklinik RWTH Aachen, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAggression in mental disorders (AMD) is a prevalent symptom, poses difficulties to the clinical setting and has far-reaching societal implications. The biological basis of different manifestations, developmental courses, and disease-specific mechanisms remains largely unknown. The lack of understanding of the complex mechanisms underlying AMD due to the heterogeneity of aggression and psychiatric disorders themselves, will be addressed by studying a longitudinal transdiagnostic cohort of patients suffering from mental disorders dimensionally quantified with respect to aggressive behavior.

methodsCapitalizing on the Research Domain Criteria "negative valence system" (NVS) and "cognitive system" (CS), multilevel measurements of behavioral and biological systems provide a harmonized dataset at three study sites (Frankfurt, Mannheim/Heidelberg, Aachen; 900 adults, 200 children/youth) including forensic satellites (n = 150). A cross-sectional matched control group (300 adults, 100 youth) will also be included. DISCUSSION: The goal of the study is to provide a multilevel characterization of patients, assessing dimensional phenotypic measures across time points and diagnoses, to finally define aggressive biosignatures.

trial registrationThe present study has been registered at https://drks.de/register/en/trial/DRKS00035731 (number of registration: DRKS00035731; date of registration: 20/02/2025).

Indexed as

AggressionMental DisordersAdolescentAdultAgedChildCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedYoung AdultAggressionCognitive systemMental disordersNegative valence system

Identifiers

PMID42816837
PMCPMC13625220

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.