Evidence map›Paper›PMID 42816692›Full record

ArticleNatural products and bioprospecting2026

A self-assembled Dendrobium polysaccharide hydrogel with anti-aging activity via the FOXO signaling pathway.

Yanye Zhang, Yuanhe Wang, Huiyan Shao, Xingli Guo, Pengcheng Xu, Yanlang Li, Jianke Jia, Fawu Dong, Jiang-Miao Hu, Liu Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Natural products and bioprospecting, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yanye Zhang *Yunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China.
Yuanhe Wang *Key Laboratory of Phytochemistry and Natural Medicines, and Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, China.
Huiyan ShaoKey Laboratory of Phytochemistry and Natural Medicines, and Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, China.
Xingli GuoKey Laboratory of Phytochemistry and Natural Medicines, and Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, China.
Pengcheng XuKey Laboratory of Phytochemistry and Natural Medicines, and Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, China.
Yanlang LiKey Laboratory of Phytochemistry and Natural Medicines, and Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, China.
Jianke JiaKey Laboratory of Phytochemistry and Natural Medicines, and Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, China.
Fawu DongYunnan Key Laboratory of Chinese Medicine Processing, College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China. dongfawu085@163.com.
Jiang-Miao HuKey Laboratory of Phytochemistry and Natural Medicines, and Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, China. hujiangmiao@mail.kib.ac.cn.
Liu YangKey Laboratory of Phytochemistry and Natural Medicines, and Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, China. yangliu@mail.kib.ac.cn.ORCID http://orcid.org/0000-0002-6644-1795

Funding

National Natural Science Foundations of China 82504628Yunnan Development and Reform Commission yfgrc202439
6 · The paper itself

Abstract

Faced with the complexity and diversity of skin aging, it is critical to investigate multi-target synergistic anti-aging products. Herein, a novel composite hydrogel with anti-aging activity was developed based on Dendrobium polysaccharide, hyaluronic acid (HA), and nicotinamide (NMN). The hydrogen bond and van der Waals force were the main driving forces in the self-assembly interaction between Dendrobium polysaccharides (DDAM-1 and DOMOS), HA, and NMN. They also were important molecular mechanisms for the gel formation of the composite hydrogel, and the results have been confirmed by ITC and molecular docking. The composite hydrogel demonstrated potent anti-aging effect on the skin in vivo and in vitro, including inhibited elastase/collagenase, promoted type I collagen secretion, prevented ROS, and reduced the expression of IL-6/MMP-3. In addition, the anti-aging mechanism of the composite hydrogel may be associated with FOXO and TGF-β/Smad- SIRT1 signaling pathways mediated by FOXO3, SIRT1, SMAD3 and TGF-β. Briefly, this study demonstrates the potential of HA-infused composite hydrogels for use as anti-aging cosmetic products due to their synergistic anti-aging strategies for anti-aging applications.

Indexed as

Anti-agingDendrobium polysaccharide composite hydrogelFOXO signaling pathway

Identifiers

PMID42816692
PMCPMC13627647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.