Evidence map›Paper›PMID 42816688›Full record

ArticleBulletin of experimental biology and medicine2026

Neurotrophic and Neuroprotective Effects of Magnesium Chelidonate and Chelidonic Acid in Cell Culture Experiments.

S V Kozin, A A Kravtsov, A V Moiseev, A D Rubailo, S V Bobrovnik, E R Vasilevskaya, A I Trofimenko, O M Lyasota

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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

S V KozinKuban State University, Krasnodar, Russia. kozinsv85@mail.ru.
A A KravtsovKuban State University, Krasnodar, Russia.
A V MoiseevI. T. Trubilin Kuban State Agricultural University, Krasnodar, Russia.
A D RubailoKuban State University, Krasnodar, Russia.
S V BobrovnikKuban State University, Krasnodar, Russia.
E R VasilevskayaV. M. Gorbatov Federal Research Center for Food Systems, Russian Academy of Sciences, Moscow, Russia.
A I TrofimenkoKuban State Medical University, Ministry of Health of the Russian Federation, Krasnodar, Russia.
O M LyasotaKuban State University, Krasnodar, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neuroprotective and neurotrophic properties of magnesium chelidonate and chelidonic acid at concentrations of 0.01 and 0.1 mM were studied. It was found that magnesium chelidonate and chelidonic acid significantly reduced cell death in primary rat cerebellar neuroglial cultures, both in a model of glutamate excitotoxicity and under conditions of oxygen-glucose deprivation. Both substances exerted a stimulatory effect on the neurotrophic processes in chicken embryo dorsal root ganglion cultures. The neuroprotective and neurotrophic effects of the tested compounds were more pronounced at a concentration of 0.01 mM. In our experiments, magnesium salt of chelidonic acid produced more potent neuroprotective and neurotrophic effects on the studied cultures than chelidonic acid.

Indexed as

chelidonic acidexcitotoxicitymagnesium complexneuritic growthoxygen-glucose deprivation

Identifiers

PMID42816688

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.