Evidence map›Paper›PMID 42816667›Full record

ArticleBreast cancer research and treatment2026

Metastatic metaplastic triple negative breast cancer response to sacituzumab govitecan and biomarker targetability.

Shivahamy Maheswaran, Aylin S Dedeoglu, Andrzej Niemierko, Rachel O Abelman, Rachel Jimenez, Olivia Rieur, Jennifer Hutchinson, Neelima Vidula, Laura M Spring, Leif W Ellisen and 4 more

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Article in Breast cancer research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Shivahamy MaheswaranDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Aylin S DedeogluMass General Brigham Cancer Institute, Harvard Medical School, Boston, MA, USA.
Andrzej NiemierkoMass General Brigham Cancer Institute, Harvard Medical School, Boston, MA, USA.
Rachel O AbelmanMass General Brigham Cancer Institute, Harvard Medical School, Boston, MA, USA.
Rachel JimenezMass General Brigham Cancer Institute, Harvard Medical School, Boston, MA, USA.
Olivia RieurMass General Brigham Cancer Institute, Harvard Medical School, Boston, MA, USA.
Jennifer HutchinsonMass General Brigham Cancer Institute, Harvard Medical School, Boston, MA, USA.
Neelima VidulaMass General Brigham Cancer Institute, Harvard Medical School, Boston, MA, USA.
Laura M SpringMass General Brigham Cancer Institute, Harvard Medical School, Boston, MA, USA.
Leif W EllisenMass General Brigham Cancer Institute, Harvard Medical School, Boston, MA, USA.
Steven J IsakoffMass General Brigham Cancer Institute, Harvard Medical School, Boston, MA, USA.
Seth A WanderMass General Brigham Cancer Institute, Harvard Medical School, Boston, MA, USA.
Aditya BardiaMass General Brigham Cancer Institute, Harvard Medical School, Boston, MA, USA.
Arielle J MedfordMass General Brigham Cancer Institute, Harvard Medical School, Boston, MA, USA. amedford@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOptimizing metaplastic breast cancer (MpBC) management remains an unmet clinical need. Current literature on MpBC response toantibody drug-conjugates is limited to individual case reports and case series. This study investigates outcomes in metastatic MpBC treated withsacituzumab govitecan (SG) and characterizes actionable targets to inform future studies.

methodsPatients (pts) with metastatic triple negative breastcancer (TNBC) treated at the Massachusetts General Hospital Cancer Center between 2000 and 2025 were assessed for MpBC and receipt of SG. MpBCcases were interrogated for biomarkers qualifying for targeted therapy: HER2-low status (IHC 1+/2+), combined positive score (CPS), and targetablegenomic variants based on next-generation sequencing of plasma and/or tissue ordered by the treating provider. Multivariable Cox regression analysisassessed the association of MpBC under SG treatment with progression-free survival (PFS) and overall survival.

resultsMpBC cases (n = 17) had anumerically shorter median PFS under SG compared to non-MpBC TNBC (n = 133) [2.6 vs. 6.8 months, p = 0.16]. While most patients with MpBC hadlimited response to SG monotherapy, two patients on SG + talazoparib had prolonged PFS. Annotation of available genomic and pathology data from allpatients with MpBC (n = 58) revealed targetable alterations including 34/56 patients with HER2-low status, 8/45 patients with germline BRCA1/2mut, and9/30 patients with somatic PIK3CAmut. MpBC response to matched therapies showed variable PFS.

conclusionTo our knowledge, this study is one ofthe largest analyses of MpBC response to SG and highlights challenges of treating rare diseases at large. Multi-institutional collaboration and inclusive trialdesign are essential to optimize treatments for MpBC.

Indexed as

Antibodies, Monoclonal, HumanizedBiomarkers, TumorCamptothecinTriple Negative Breast NeoplasmsAdultAgedErb-b2 Receptor Tyrosine KinasesFemaleHumansImmunoconjugatesMetaplasiaMiddle AgedMolecular Targeted TherapyNeoplasm MetastasisTreatment OutcomeAntibodies, Monoclonal, HumanizedBiomarkers, TumorCamptothecinErb-b2 Receptor Tyrosine KinasesImmunoconjugatessacituzumab govitecanAntibody–drug conjugatesGenomic profilingMetaplastic breast cancerSacituzumab govitecanTriple-negative breast cancer

Identifiers

PMID42816667

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.