Evidence map›Paper›PMID 42816627›Full record

ArticleNature2026

A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation.

Alessandra Esposito, Ibrahim Bayramoglu, Chiara Varriale, Maria Pia Cavaliere, Maria Elsa Brunetti, Rossella Agostinis, Rachel M Jansen, Dan A Tudorica, Yongjia Duan, Martina Spacci and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Alessandra EspositoTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.ORCID http://orcid.org/0000-0002-3838-7242
Ibrahim BayramogluDepartment of Biology, University of Fribourg, Fribourg, Switzerland.
Chiara VarrialeTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.
Maria Pia CavaliereTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.
Maria Elsa BrunettiTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.
Rossella AgostinisTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.
Rachel M JansenDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
Dan A TudoricaDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
Yongjia DuanDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
Martina SpacciDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0009-0006-2928-0159
Alessia CalcagnìTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.ORCID http://orcid.org/0000-0002-1946-5815
Carolin D StroblDepartment of Medicine III, Ludwig-Maximilians-University (LMU) Hospital, Munich, Germany.
Verena PasseriniDepartment of Medicine III, Ludwig-Maximilians-University (LMU) Hospital, Munich, Germany.
Fabrizio AndreoneTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.ORCID http://orcid.org/0009-0009-3960-3910
Jlenia MonfregolaTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.
Julia RichterHematopathology Section, Dpt. of Pathology, University Hospital Schleswig-Holstein (UKSH), Kiel, Germany.ORCID http://orcid.org/0000-0002-9543-4084
Francesca SaccoTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.ORCID http://orcid.org/0000-0001-5586-9529
Wolfram KlapperHematopathology Section, Dpt. of Pathology, University Hospital Schleswig-Holstein (UKSH), Kiel, Germany.ORCID http://orcid.org/0000-0001-7208-4117
Oliver WeigertDepartment of Medicine III, Ludwig-Maximilians-University (LMU) Hospital, Munich, Germany.ORCID http://orcid.org/0000-0002-0987-7373
Andrea BallabioTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.ORCID http://orcid.org/0000-0003-1381-4604
Roberto ZoncuDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-1611-1891
James H HurleyDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-5054-5445
Joern DengjelDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0000-0002-9453-4614
Gennaro NapolitanoTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy. g.napolitano@tigem.it.ORCID http://orcid.org/0000-0002-8615-4654

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysosomal adaptation to environmental changes is critical for cellular and metabolic homeostasis and requires coordination by the mTORC1 kinase, which conveys nutritional and stress signals into distinct, substrate-specific outputs

Identifiers

PMID42816627

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.