Evidence map›Paper›PMID 42816614›Full record

ArticleNature2026

γδ T cell receptor dependencies define a unique immunosurveillance modality.

Nicolas Veland, Bethania Garcia-Cassani, Ángela Zarco-Cuadrillero, Annamaria Mavrigiannaki, Ambra Natalini, Josephine Eum, Alejandro Suarez-Bonnet, Pierre Vantourout, Duncan R McKenzie, Jannik Franken and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nicolas Veland *Peter Gorer Department of Immunobiology, King's College London, London, UK.
Bethania Garcia-Cassani *Development and Homeostasis of the Nervous System Laboratory, The Francis Crick Institute, London, UK.
Ángela Zarco-CuadrilleroDepartment of Immunology, Ophthalmology and Ear, Nose and Throat, Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain.
Annamaria MavrigiannakiImmunosurveillance Laboratory, The Francis Crick Institute, London, UK.
Ambra NataliniPeter Gorer Department of Immunobiology, King's College London, London, UK.
Josephine EumPeter Gorer Department of Immunobiology, King's College London, London, UK.
Alejandro Suarez-BonnetExperimental Histopathology, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-0296-5896
Pierre VantouroutPeter Gorer Department of Immunobiology, King's College London, London, UK.ORCID http://orcid.org/0000-0001-7287-5517
Duncan R McKenzieImmunosurveillance Laboratory, The Francis Crick Institute, London, UK.
Jannik FrankenImmunosurveillance Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0009-0006-2460-2841
Ana V MarinDepartment of Immunology, Ophthalmology and Ear, Nose and Throat, Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain.ORCID http://orcid.org/0000-0002-7541-3729
Anett JandkeDepartement Biomedizin, University of Basel, Basel, Switzerland.
Rosa Andrés-EjarqueCRUK City of London Cancer Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0012-1155
Jessica StridDepartment of Immunology and Inflammation, Imperial College, London, UK.ORCID http://orcid.org/0000-0003-3690-2201
Adrian C HaydayPeter Gorer Department of Immunobiology, King's College London, London, UK. Adrian.Hayday@crick.ac.uk.ORCID http://orcid.org/0000-0002-9495-5793
Miguel Muñoz-RuizImmunosurveillance Laboratory, The Francis Crick Institute, London, UK. miguel.munoz@cbm.csic.es.ORCID http://orcid.org/0000-0001-7986-3527

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γδ T cells are one of three lymphocyte lineages that utilize gene rearrangement to diversify their antigen receptors. Nonetheless, the cells' classification has remained uncertain, complicating our ability to understand the basis for their evolutionary conservation. Whereas many γδ T cells display hallmarks of adaptive immunity, others, including those in barrier tissues, make rapid, reportedly T cell receptor-independent responses that phenocopy innate immune cells

Identifiers

PMID42816614

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.