ArticleNature2026
Human genetics implicates a BACH2-NRF2 axis in fetal haemoglobin activation.
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Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
54 authors.
Chun-Jie Guo *Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Uma P Arora *Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Xiaoheng ChengDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Wanying XuDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0009-5240-9629
Liam D CatoDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Rick LiDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Henry Y LuDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Andrew J LeeDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9917-8834
Fulong YuDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Gaurav AgarwalDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Peng LyuDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Tianyi YeDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Mateusz AntoszewskiDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7651-0547
Mariel WissmannDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Baraka S MkumbeSickle Cell Program, Department of Hematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID http://orcid.org/0000-0003-4838-5731
Supachai EkwattanakitSiriraj Thalassemia Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Patrick DeelenDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Liberata MwitaDepartment of Pharmaceutical Microbiology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Raphael SangedaSickle Cell Program, Department of Hematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID http://orcid.org/0000-0002-6574-5308
Thidarat SuksangplengSiriraj Thalassemia Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Suchada RiolueangSiriraj Thalassemia Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Paola G BronsonR&D Translational Biology, Biogen, Cambridge, MA, USA.
Dirk S PaulBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8230-0116
Emily KawabataBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
William J AstleBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Francois AguetBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Kristin ArdlieBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Aitzkoa Lopez de Lapuente PortillaLund Stem Cell Center, Lund University, Lund, Sweden.
Guolian KangSt. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-6102-0115
Yingze ZhangDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-6947-2901
Seyed Mehdi NouraieDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-7465-0581
Victor R GordeukDivision of Hematology and Oncology, Department of Medicine, Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4725-7295
Mark T GladwinDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7267-9006
Melanie E GarrettDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Allison Ashley-KochDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0001-5409-9155
Marilyn J TelenDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0003-3809-1780
Brian CusterVitalant Research Institute, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6251-366X
Shannon KellyVitalant Research Institute, San Francisco, CA, USA.
Carla Luana DinardoFundacao Pro-Sangue Hemocentro de Sao Paulo, Sao Paulo, Brazil.
Ester C SabinoInstitute of Tropical Medicine, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.ORCID http://orcid.org/0000-0003-2623-5126
Paula LoureiroFundacao Hemope, Recife, Brazil.
Anna Bárbara Carneiro-ProiettiFundacao Hemominas, Belo Horizonte, Brazil.
Cláudia MaximoFundacao Hemorio, Rio de Janeiro, Brazil.
Adriana MéndezInstitute of Laboratory Medicine, Cantonal Hospital Aarau, Aarau, Switzerland.
Angelika Hammerer-LercherInstitute of Laboratory Medicine, Cantonal Hospital Aarau, Aarau, Switzerland.
Julie MakaniSickle Cell Program, Department of Hematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Vivien A SheehanAflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta & Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-2837-2255
Mitchell J WeissSt. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-2460-3036
Lude FrankeDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-5159-8802
Björn NilssonBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5542-0254
Adam S ButterworthBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6915-9015
Vip ViprakasitSiriraj Thalassemia Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Siana NkyaSickle Cell Program, Department of Hematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID http://orcid.org/0000-0001-7576-6279
Vijay G SankaranDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. sankaran@broadinstitute.org.ORCID http://orcid.org/0000-0003-0044-443X
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human genetic studies have identified key regulators of fetal haemoglobin (HbF) expression, including BCL11A, resulting in therapeutic advances
Identifiers
PMID
42816612What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.