Evidence map›Paper›PMID 42816608›Full record

ArticleNature2026

Transcription pause and elongation regulators mediate somatic hypermutation.

Lizhen Wu, Anurupa Devi Yadavalli, Caillan C McAuliffe, Qi Ha, Mahsa Nouri Barkestani, Foad Rommasi, Isaac Fianu, Filip Senigl, David G Schatz

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lizhen WuDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA. lizhen.wu@yale.edu.ORCID http://orcid.org/0000-0002-7832-465X
Anurupa Devi YadavalliDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Caillan C McAuliffeDepartment of Molecular Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID http://orcid.org/0000-0003-2157-4639
Qi HaDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Mahsa Nouri BarkestaniDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Foad RommasiDepartment of Molecular Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID http://orcid.org/0000-0001-7189-170X
Isaac FianuDepartment of Molecular Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID http://orcid.org/0000-0002-8508-114X
Filip SeniglInstitute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska, Prague, Czech Republic.ORCID http://orcid.org/0009-0007-1745-1261
David G SchatzDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA. david.schatz@yale.edu.ORCID http://orcid.org/0000-0002-5669-1176

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Somatic hypermutation (SHM) creates point mutations in the variable regions of immunoglobulin genes in activated B cells to support antibody affinity maturation

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.