Evidence map›Paper›PMID 42816607›Full record

ArticleNature2026

Prion-like transmission of human tau strains in the mouse brain.

Sofia Lövestam, Aki Shimozawa, Airi Tarutani, Reiko Ohtani, Masami Masuda-Suzukake, Kazuko Hasegawa, Andrew C Robinson, Yuko Saito, Shigeo Murayama, Mari Yoshida and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sofia Lövestam *MRC Laboratory of Molecular Biology, Cambridge, UK.
Aki Shimozawa *Laboratory of Neuropathology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID http://orcid.org/0009-0002-7704-9956
Airi Tarutani *Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Reiko OhtaniDepartment of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Masami Masuda-SuzukakeDepartment of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Kazuko HasegawaDivision of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan.
Andrew C RobinsonFaculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0003-2208-7728
Yuko SaitoDepartment of Neuropathology (The Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.ORCID http://orcid.org/0000-0002-9974-8638
Shigeo MurayamaDepartment of Neuropathology (The Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Mari YoshidaDepartment of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Aichi, Japan.
Hisaomi SuzukiDepartment of Psychiatry, National Hospital Organization Shimofusa Psychiatric Center, Chiba, Japan.
Mitsumoto OnayaDepartment of Psychiatry, National Hospital Organization Shimofusa Psychiatric Center, Chiba, Japan.
Masato HasegawaLaboratory of Neuropathology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan. hasegawa-ms@igakuken.or.jp.ORCID http://orcid.org/0000-0001-7415-8159
Michel GoedertMRC Laboratory of Molecular Biology, Cambridge, UK. mg@mrclmb.ac.uk.ORCID http://orcid.org/0000-0002-5214-7886
Sjors H W ScheresMRC Laboratory of Molecular Biology, Cambridge, UK. scheres@mrclmb.ac.uk.ORCID http://orcid.org/0000-0002-0462-6540

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most neurodegenerative diseases are thought to spread through the brain by prion-like mechanisms, in which filamentous protein assemblies self-propagate by templated seeding

Identifiers

PMID42816607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.