Evidence map›Paper›PMID 42816584›Full record

ArticleNature immunology2026

Prefibrotic bone marrow microenvironment is a hallmark of clonal hematopoiesis.

Alicia G Aguilar-Navarro, Gibran Edun, Mark Gower, Joan Kant, Ximing Li, Dustin Yang, Mursal Nader, Minerva Fernandez, Soheil Jahangiri, Emily Tsao and 24 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Alicia G Aguilar-Navarro *Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Gibran Edun *Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Mark GowerPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Joan KantPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0009-0007-1837-5854
Ximing LiPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Dustin YangPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Mursal NaderPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Minerva FernandezPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0009-0003-6830-9477
Soheil JahangiriPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Emily TsaoPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Pratik JoshiPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Pathum KossinnaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Loic Cameron CalorenPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
John Roderick DaveyDivision of Orthopedic Surgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Michael G ZywielDivision of Orthopedic Surgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
R Peter SudermanDepartment of Materials Science and Engineering, University of Toronto, Toronto, Ontario, Canada.
Anoushka I KapoorFaculty of Arts and Science, University of Toronto, Toronto, Ontario, Canada.
Margarete K AkensPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Adele ChangoorDepartment of Materials Science and Engineering, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-0175-6227
Minna WooDepartment of Immunology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Robert F StanleyMolecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-2308-6914
Kira A YoungThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID http://orcid.org/0000-0002-1598-9793
Christine TranPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Valentin SotovPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Ben X WangPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Sagi AbelsonOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Omar Abdel-WahabMolecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-3907-6171
Shruti NaikDepartment of Immunology and Immunotherapy, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-2216-5135
Jennifer J TrowbridgeThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID http://orcid.org/0000-0002-7636-9504
Robert VannerPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Kristin J HopePrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Hubert TsuiDepartment of Immunology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Federico GaitiPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-5111-8816
Anastasia N TikhonovaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Anastasia.Tikhonova@uhn.ca.ORCID http://orcid.org/0000-0001-6712-1606

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-185950Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-203948;180406
6 · The paper itself

Abstract

Clonal hematopoiesis of indeterminate potential is associated with systemic inflammation and increased malignant risk in humans, yet understanding of how it reshapes the bone marrow (BM) microenvironment has been limited. Using single-cell transcriptomic profiling of freshly isolated BM samples, combined with histological and spatial transcriptomic analyses, we identified fibro-inflammatory remodeling as a hallmark of clonal hematopoiesis of indeterminate potential. Fibroblasts were markedly expanded and acquired cancer-associated fibroblast-like transcriptional states, while mesenchymal and vascular cells upregulated collagen production and extracellular matrix remodeling pathways. Spatial transcriptomics revealed discrete fiber-enriched regions populated by active and CXCL12

Identifiers

PMID42816584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.