Evidence map›Paper›PMID 42816580›Full record

ArticleNature microbiology2026

Innate immune sensing of Plasmodium sporozoite cell traversal drives protective T cell responses.

Kai G Pohl, Xin Gao, Jason McGowan, Parnika Mukherjee, Shirley Le, Patricia Carreira, Chinh Ngo, Henry J Sutton, Sophia Brumhard, Anna Hiller and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Kai G PohlDivision of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0001-5766-7226
Xin GaoDivision of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Jason McGowanDivision of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Parnika MukherjeeDepartment of Infectious Diseases and Critical Care Medicine, Charité - University Medical Center Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-5365-9541
Shirley LeDepartment of Microbiology and Immunology and The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0009-0007-8236-2222
Patricia CarreiraDivision of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Chinh NgoDivision of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Henry J SuttonDivision of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Sophia BrumhardDepartment of Infectious Diseases and Critical Care Medicine, Charité - University Medical Center Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Anna HillerDepartment of Infectious Diseases and Critical Care Medicine, Charité - University Medical Center Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Hannah G KellyDivision of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Larissa LiowDivision of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Adrian LoDivision of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0009-0006-1921-0616
Larissa HenzeDer Simulierte Mensch, Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Lucie LoyalDer Simulierte Mensch, Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-5738-4437
Rogerio AminoInstitut Pasteur, Université Paris Cité, INSERM U1347, Malaria Infection and Immunity, BioSPC, ParasitInnov, Paris, France.ORCID http://orcid.org/0000-0002-8086-2932
Si Ming ManDivision of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0002-5079-2857
Lynette BeattieDepartment of Microbiology and Immunology and The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-5794-7233
Leif Erik SanderDepartment of Infectious Diseases and Critical Care Medicine, Charité - University Medical Center Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-0476-9947
Ian A CockburnDivision of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia. ian.cockburn@anu.edu.au.ORCID http://orcid.org/0000-0001-8220-9294

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-10-LABX-62-IBEIDDepartment of Education and Training | Australian Research Council (ARC) DP220103545Department of Health | National Health and Medical Research Council (NHMRC) 1105817Department of Health | National Health and Medical Research Council (NHMRC) 2002682Department of Health | National Health and Medical Research Council (NHMRC) 2008648Deutsche Forschungsgemeinschaft (German Research Foundation) IRTG2290
6 · The paper itself

Abstract

Attenuated Plasmodium sporozoites (SPZs) are being tested as a potential malaria vaccine as they elicit robust adaptive immune responses that protect against parasite challenge. Yet how they engage the innate immune system remains poorly understood. Here we isolated pure GFP

Identifiers

PMID42816580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.