ArticleNature communications2026
Multilayer mesoporous vesosomes of block copolymer.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Multilayer mesoporous vesosomes uniquely combine hollow multilayer shells with ordered mesopores, providing a basis for multilevel gating, controlled release, and programmed reaction cascades, yet robust construction remains challenging. Herein, we report a molecular engineering strategy based on 3D-confined self-assembly to produce multilayer vesosomes with nearly hexagonally ordered shell perforations. Selective association of pentadecylphenol (PDP) and 1,5-dibromopentane (DBP) with the poly(4-vinylpyridine) block precisely tunes block-copolymer volume fraction to stabilize an unconventional perforated lamellar morphology, while reversible hydrogen bonding enables region-selective pore generation. Experiments and simulations reveal cooperative roles of confinement and hydrogen bonding in directing morphological evolution, with DBP further refining assembly through electrostatic and cross-linking interactions. The resulting multilayer mesoporous vesosomes feature a pyridine-rich corona and show iodine capture (1.26 g g
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