ArticleNature communications2026
Effect of liposome rigidity on corona formation and its implications for uptake by cells.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Effect of liposome rigidity on corona formation and its implications for uptake by cells.Nature communications · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoparticle rigidity influences cellular uptake and in vivo behavior, yet the underlying mechanisms remain unclear. Here we used lipids with identical head groups but different acyl chains to prepare liposomes with comparable surface composition, size and zeta potential, but distinct mechanical properties. Rigid liposomes showed much higher uptake than soft ones, mediated by distinct endocytic mechanisms. Proteomic analysis revealed that rigid and soft liposomes adsorbed very different coronas upon dispersion in serum. RNA interference and competition studies indicated that the enhanced uptake of rigid liposomes is likely driven by the lower abundance of multiple apolipoproteins in their corona, and possibly the higher abundance of apolipoprotein H and of a pattern of low-abundant corona proteins. Importantly, a strong difference in uptake was observed only when liposomes were added to cells in the presence of serum. Hence, the different uptake efficiency is not solely due to the different mechanical properties, but results from the effect of liposome mechanical properties on corona formation.
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