Evidence map›Paper›PMID 42816471›Full record

ArticleSignal transduction and targeted therapy2026

Targeting the HPGDS-PGD

Yuxin Zhuang, Kawai Lei, Yan Li, Wende Deng, Jianmin Yue, Jianbo Wan, Qibiao Wu, Qianjin Lu, Yun Tang, John E J Rasko and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Signal transduction and targeted therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuxin Zhuang *State Key Laboratory of Mechanism and Quality of Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau, SAR, China.
Kawai Lei *State Key Laboratory of Mechanism and Quality of Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau, SAR, China.
Yan Li *State Key Laboratory of Mechanism and Quality of Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau, SAR, China.
Wende DengState Key Laboratory of Mechanism and Quality of Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau, SAR, China.
Jianmin YueState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Jianbo WanState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, SAR, China.ORCID http://orcid.org/0000-0002-6750-2617
Qibiao WuFaculty of Chinese Medicine, Macau University of Science and Technology, Macau, SAR, China.
Qianjin LuHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Yun TangShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
John E J RaskoBiomedical Pioneering Innovation Center (BIOPIC), and School of Life Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0000-0003-3181-7198
Juan LiuState Key Laboratory of Mechanism and Quality of Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau, SAR, China.
Olivia MonteiroFaculty of Medicine, Macau University of Science and Technology, Macau, SAR, China.ORCID http://orcid.org/0000-0003-0191-5547
Xiqing BianState Key Laboratory of Mechanism and Quality of Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau, SAR, China.
Wei QiuDepartment of Neurology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. qiuwei@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-0880-958X
Ting LiState Key Laboratory of Mechanism and Quality of Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau, SAR, China. tli@must.edu.mo.ORCID http://orcid.org/0000-0003-4990-5997

Funding

Fundo para o Desenvolvimento das Ciências e da Tecnologia (Science and Technology Development Fund) 0003/2021/AKPFundo para o Desenvolvimento das Ciências e da Tecnologia (Science and Technology Development Fund) 0003/2025/NRPFundo para o Desenvolvimento das Ciências e da Tecnologia (Science and Technology Development Fund) 0018/2023/AMJFundo para o Desenvolvimento das Ciências e da Tecnologia (Science and Technology Development Fund) 043/2024/AGJ
6 · The paper itself

Abstract

Th17 cells are central drivers of autoimmune pathology, including multiple sclerosis (MS), yet the endogenous metabolic signals that shape their pathogenic differentiation remain incompletely defined. Prostaglandin D₂ (PGD

Indexed as

AutoimmunityEncephalomyelitis, Autoimmune, ExperimentalIntramolecular OxidoreductasesMultiple SclerosisProstaglandin D2Th17 CellsAnimalsCell DifferentiationFemaleHumansLipocalinsMicePPAR gammaIntramolecular OxidoreductasesLipocalinsPPAR gammaProstaglandin D2prostaglandin R2 D-isomerase

Identifiers

PMID42816471
PMCPMC13627710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.