Evidence map›Paper›PMID 42816054›Full record

SynthesisJournal of the International Society of Sports Nutrition2026

Effects of acute Capsaicin analogue intake on athletic performance: a three-level meta-analysis.

Zhu Huang, Hengzhi Deng, Shuiquan Tan

Abstract readMeta-Analysis
In one paragraph

Synthesis in Journal of the International Society of Sports Nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhu HuangSchool of Sports Science, Nanjing Normal University, Nanjing, People's Republic of China.ORCID 0009-0009-6520-3718
Hengzhi DengFaculty of Sports and Exercise Science, University of Malaya, Kuala Lumpur, Malaysia.
Shuiquan TanCollege of Physical Education, JiaYing University, Guangdong, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCapsaicin analogues have been proposed as potential ergogenic aids, but their acute effects on athletic performance remain inconsistent. This study aimed to evaluate the effects of acute capsaicin analogue intake on exercise performance using a three-level meta-analysis.

methodsPubMed, Web of Science, Scopus, SPORTDiscus, and the Cochrane Library were searched up to April 1, 2025. Randomized controlled trials examining acute oral capsaicin analogue intake in healthy adults were included. Outcomes were classified into strength, power, muscular endurance, and aerobic capacity. Hedges' g was calculated using a three-level random-effects model.

resultsTwenty-one randomized crossover trials with 67 effect sizes were included. Acute capsaicin analogue intake significantly improved overall athletic performance compared with placebo (g = 0.20, 95% CI [0.07, 0.33],

conclusionsAcute capsaicin analogue intake may produce small but significant improvements in athletic performance, particularly in power and muscular endurance. However, due to heterogeneity, publication bias, and very low certainty of evidence, these findings should be interpreted cautiously.

Indexed as

Athletic PerformanceCapsaicinPerformance-Enhancing SubstancesDose-Response Relationship, DrugHumansMuscle StrengthPhysical EnduranceRandomized Controlled Trials as TopicCapsaicinPerformance-Enhancing SubstancesCapsaicin analoguesdose-response relationshipsports performancethree-level meta-analysisTRPV1 agonist

Identifiers

PMID42816054
PMCPMC13629781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.