Evidence map›Paper›PMID 42815543›Full record

ArticleBiofabrication2026

Airflow controlled droplet bioprinting enables high-throughput generation of iPSC-derived thymic organoids with

Miranda Poklar, Erin Parlow, Ravikumar K, Nathan Ligenfelter, Mirabella Stump, Elyse Barnes, Lydia Kutzer, Wen Liu, Jiahui Dai, Lauren McCarthy and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biofabrication, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Miranda PoklarDepartment of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, United States of America.
Erin ParlowDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States of America.
Ravikumar KDepartment of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, United States of America.
Nathan LigenfelterDepartment of Biomedical Engineering, Duquesne University, Pittsburgh, PA, United States of America.ORCID 0009-0002-2666-4983
Mirabella StumpDepartment of Biomedical Engineering, Duquesne University, Pittsburgh, PA, United States of America.
Elyse BarnesDepartment of Biomedical Engineering, Duquesne University, Pittsburgh, PA, United States of America.
Lydia KutzerDepartment of Biomedical Engineering, Duquesne University, Pittsburgh, PA, United States of America.ORCID 0009-0004-8375-5659
Wen LiuCancer Institute, Allegheny Health Network, Pittsburgh, PA, United States of America.
Jiahui DaiDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States of America.ORCID 0009-0007-4096-1104
Lauren McCarthyDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, United States of America.ORCID 0009-0009-2627-8063
Carl EngmanDepartment of Biomedical Engineering, Duquesne University, Pittsburgh, PA, United States of America.ORCID 0000-0002-5676-5307
Prashant N KumtaDepartment of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, United States of America.
Kimberly F WilliamsDepartment of Biomedical Engineering, Duquesne University, Pittsburgh, PA, United States of America.ORCID 0000-0002-2431-7948
Yong FanCancer Institute, Allegheny Health Network, Pittsburgh, PA, United States of America.
Bin YangDepartment of Biomedical Engineering, Duquesne University, Pittsburgh, PA, United States of America.
Ipsita BanerjeeDepartment of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, United States of America.ORCID 0000-0001-6791-3646

Funding

Cardiovascular Bioengineering Training ProgramT32HL076124 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANJEEV G SHROFF · 2005 to 2026
$7.0M
Novel hematopoietic humanized mouse model to study CAR-T therapy-associated cytokine release syndromeR21OD034476 · OD · ALLEGHENY-SINGER RESEARCH INSTITUTE · PI FAN, YONG · 2023 to 2024
$445k
NHLBI NIH HHS T32 HL076124NIH HHS R21 OD034476
6 · The paper itself

Abstract

The thymus is a critical organ for T cell generation. It is composed of distinct layers of thymic epithelial cells (TECs) that coordinate a complex process of antigen recognition and self-tolerance checks that result in mature populations of T cells. However, it undergoes progressive and permanent involution and loss of functionality which peaks in adolescence, rendering the tissue largely non-functional. Induced pluripotent stem cells (iPSCs) have emerged as promising candidates to generate organoid models of the thymus because of their autologous potential and indefinite self-renewal. Previously our group has shown the capability of generating thymic epithelial progenitor cells (TEPCs) that are able to successfully program T cells

Indexed as

BioprintingInduced Pluripotent Stem CellsOrganoidsThymus GlandAnimalsCell DifferentiationEpithelial CellsHumansMiceT-Lymphocytesdroplet printinginduced pluripotent stem cellsorgan regenerationthymic epithelial organoids

Identifiers

PMID42815543
PMCPMC13660416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.