ArticleCurrent biology : CB2026
Mitotic shape changes drive spatiotemporally segregated cell-contact rearrangements in a proliferating epithelium.
Article in Current biology : CB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
In animals, epithelial tissue morphology is determined by the shape, position, and number of its component cells. Nevertheless, it remains incompletely understood how the shape transformations that accompany epithelial mitosis influence tissue packing. Combining an in silico vertex model with live imaging of murine intestinal organoids, we show that mitotic shape changes drive a spatiotemporally segregated sequence of cell-contact rearrangements: basal diminution of mitotic cells, transient multicellular rosette assembly, and reinsertion of the daughter cells. Strikingly, the reinsertion is accompanied by neighbor exchanges oriented perpendicular to the daughter-daughter contact in silico and in organoids, which indicates that reinsertion geometry is sufficient to set the direction of rearrangement. Pharmacological arrest of mitotic progression reveals that basal diminution and daughter reinsertion independently drive distinct contact rearrangements. Together, our results establish that two distinct geometric asymmetries of mitosis, the apico-basal diminution of the dividing cell and the in-plane anisotropy of daughter reinsertion, drive a program of cell rearrangement that reorganizes basal cell-contact topology, thus providing an intrinsic route by which proliferating epithelia accommodate new cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.