ArticleNeuron2026
Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids.
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Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
26 authors.
Xiaoling ChenBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Jingliang ZhangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Jiaxiang WuBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Morgan J RobinsonBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA; Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Harish KothandaramanPurdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Ye-Eun YooBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Iria M Gonzalez Dopeso-ReyesInstitut de Génétique Moléculaire de Montpellier, Université de Montpellier, CNRS UMR 5535, 34090 Montpellier, France.
Thomas D BuffenoirInstitut de Génétique Moléculaire de Montpellier, Université de Montpellier, CNRS UMR 5535, 34090 Montpellier, France.
Manasi S HalurkarBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Hui YangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Zaiyang ZhangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Muhan WangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Erin N CreagerCollege of Science, Purdue University, West Lafayette, IN 47907, USA.
Harris D GilesDepartment of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA.
Yuanrui ZhaoBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Maria I Olivero-AcostaBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Kyle W WettschurackBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Zhefu QueBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Jing LiuDepartment of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA.
Chongli YuanPurdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA; Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Allison J SchaserPurdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA; Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN 47907, USA.
Nadia A LanmanPurdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Jean-Christophe RochetBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
William C SkarnesThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Eric J KremerInstitut de Génétique Moléculaire de Montpellier, Université de Montpellier, CNRS UMR 5535, 34090 Montpellier, France.
Yang YangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address: yangyang@purdue.edu.
Funding
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3MTransgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4MNeuronal and Behavioral Deficits Associated with Scn2a Deficiency in Autism Spectrum DisorderR01NS117585 · NINDS · PURDUE UNIVERSITY · PI YANG, YANG · 2021 to 2025
$2.0MNeuronal hyperexcitability and seizures in a Scn2a deficient mouse modelR01NS123154 · NINDS · PURDUE UNIVERSITY · PI YANG, YANG · 2021 to 2025
$1.9MDual-AAV gene replacement for SCN2A disordersR56NS144233 · NINDS · PURDUE UNIVERSITY · PI Yang Yang · 2026 to 2026
$546kNCI NIH HHS P30 CA023168NCI NIH HHS P30 CA082709NINDS NIH HHS R01 NS117585NINDS NIH HHS R01 NS123154NINDS NIH HHS R56 NS144233
Abstract
Profound autism spectrum disorder (ASD) is frequently attributable to single-gene mutations, with SCN2A, encoding the voltage-gated sodium channel Na
Indexed as
assembloidautismbrain organoidcanine adenovirus type 2cortico-striatal circuitgene replacementNa(V)1.2neuronal excitabilitySCN2A
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.