ArticleJournal of acquired immune deficiency syndromes (1999)2026
Missed opportunities for PrEP among the partners of people newly initiated in HIV care in western Tanzania.
Article in Journal of acquired immune deficiency syndromes (1999), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04201353 (Optimizing the Efficiency and Implementation of Cash Transfers to Improve Adherence to Antiretroviral Therapy, Phase II), which is not on this map. Not yet cited in PubMed.
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Optimizing the Efficiency and Implementation of Cash Transfers to Improve Adherence to Antiretroviral Therapy, Phase II: Effectiveness Study
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12 authors.
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Abstract
introductionPre-exposure prophylaxis (PrEP) has the potential to significantly reduce incident HIV globally, especially among individuals in sero-discordant partnerships with repeated HIV exposure and/or whose partners are not virally suppressed (undermining "Undetectable = Untransmittable"). Partner-based referrals may enhance PrEP uptake, yet data on PrEP awareness and willingness among people living with HIV (PLHIV) in east Africa is limited. We assessed PrEP knowledge and willingness to support partner uptake of PrEP among antiretroviral therapy (ART) initiates in Tanzania.
methodsData were from the Afya II cluster RCT, which recruited ART initiates (n=1,990) randomized to usual care or monthly cash incentives for clinic visits. At the twelve-month visit, participants completed a sub-section on PrEP knowledge and attitudes, partner PrEP use, and understanding of U=U. We used multivariable regression to analyze correlates of U=U agreement (linear) and PrEP awareness (logistic).
resultsOver half (59%) of participants had never heard of PrEP and 52% were in sero-discordant relationships. Among those in sero-discordant relationships, 22% reported their partner PrEP use. Participants showed high support for partner PrEP use (70% very supportive). Median U=U agreement was high (4.0/5.0). Female sex was associated with higher U=U concordance (β=0.84, 95%CI: 0.73-0.97). Among those in sero-discordant relationships, PrEP awareness was higher among those with greater education (AOR=2.91, 95%CI: 1.21-6.98).
conclusionsPrEP awareness was low despite over half of participants being in sero-discordant partnerships. Ensuring PrEP promotion during routine HIV care visits, particularly among ART initiates who have yet to achieve viral suppression, may support secondary prevention of HIV efforts. CLINICAL TRIAL NUMBER: NCT04201353.
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