Evidence map›Paper›PMID 42814836›Full record

ArticleScience advances2026

Systematic identification of p11 as a signaling modulator across the GPCRome.

Marcus Saarinen, Ilana B Kotliar, Inga Höffkes, Niclas Branzell, Carl-Fredrik Bowin, Leo Dahl, Elisa Da Silva, Vassilis Glaros, Alonso Abney, Annika Bendes and 4 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marcus SaarinenDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-9019-8396
Ilana B KotliarLaboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-9533-4828
Inga HöffkesDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Niclas BranzellDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0009-0009-3472-6903
Carl-Fredrik BowinDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-9090-9493
Leo DahlScience for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden.ORCID 0000-0003-1492-3052
Elisa Da SilvaDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0009-0006-0105-2402
Vassilis GlarosDepartment of Medicine Solna, Division of Immunology and Respiratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Alonso AbneyDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-0164-8314
Annika BendesScience for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden.ORCID 0000-0001-9329-2353
Taras KreslavskyDepartment of Medicine Solna, Division of Immunology and Respiratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-6672-1914
Jochen M SchwenkScience for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden.ORCID 0000-0001-8141-8449
Thomas P SakmarLaboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-2836-8953
Per SvenningssonDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6727-3802

Funding

Tri-Institutional PhD Program in Chemical BiologyT32GM136640 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEREK S TAN · 2020 to 2026
$2.4M
NIGMS NIH HHS T32 GM136640
6 · The paper itself

Abstract

The microprotein p11 (

Indexed as

Receptors, G-Protein-CoupledS100 Calcium Binding Protein A10Sensory Receptor CellsAnimalsFemaleHEK293 CellsHumansMaleMiceMice, KnockoutProtein ConformationReceptor, PAR-2Receptors, SerotoninSingle-Cell Gene Expression AnalysisReceptor, PAR-2Receptors, G-Protein-CoupledReceptors, SerotoninS100 Calcium Binding Protein A10

Identifiers

PMID42814836
PMCPMC13626081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.