Evidence map›Paper›PMID 42814831›Full record

ArticleScience advances2026

Remodeling of mitochondrial dynamics by metabolic pathways couples to oncogenic growth in

Grant A Hagedorn, Jackson C Spieser, Noriko Hirai, Yuki Sato, Jake Valentine, Hanson Jiang, Wang Wang, Maria F Czyzyk-Krzeska, Krushna C Patra

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Grant A HagedornDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0002-7238-7801
Jackson C SpieserDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0009-0009-5789-2605
Noriko HiraiDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0002-5175-0800
Yuki SatoDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jake ValentineDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Hanson JiangDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0009-0004-2116-9013
Wang WangMitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9093-412X
Maria F Czyzyk-KrzeskaDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0002-0693-8214
Krushna C PatraDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0002-2386-6435

Funding

Metabolic effects of cooper in renal cancerR01CA287260 · NCI · UNIVERSITY OF CINCINNATI · PI Maria F Czyzyk-Krzeska · 2023 to 2026
$2.2M
Investigating the molecular mechanisms of growth in GNAS mutant pancreatic cancer.R37CA272854 · NCI · UNIVERSITY OF CINCINNATI · PI Krushna Chandra Patra · 2022 to 2026
$1.8M
Investigation of the mitochondrial function in GNAS mutant neoplasmsK22CA237817 · NCI · UNIVERSITY OF CINCINNATI · PI PATRA, KRUSHNA CHANDRA · 2021 to 2023
$533k
BLRD VA I01 BX001110NCI NIH HHS K22 CA237817NCI NIH HHS R01 CA287260NCI NIH HHS R37 CA272854
6 · The paper itself

Abstract

Maintenance of fissed mitochondria is viewed as a defining feature of Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutant cancers. However, regulation of this process by accompanying comutations or environmental factors is not clearly defined. Here, by analyzing a subset of pancreatic cancer lesions driven by concurrent Kras

Indexed as

ChromograninsGTP-Binding Protein alpha Subunits, GsMetabolic Networks and PathwaysMitochondrial DynamicsMutationPancreatic NeoplasmsAmino Acids, Branched-ChainAnimalsCell Line, TumorCitric Acid CycleHumansMiceMitochondriaNADProto-Oncogene Proteins p21(ras)Amino Acids, Branched-ChainChromograninsGNAS protein, humanGTP-Binding Protein alpha Subunits, GsNADProto-Oncogene Proteins p21(ras)

Identifiers

PMID42814831
PMCPMC13626046

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.