Silver(I)-mediated amide-to-ester transformation on unprotected peptides for protein chemical synthesis and engineering.

Zhenquan Sun, Wai Yin Yau, Huajie Kang, Haiyan Zhou, Xin Liu, Zhibo Han, Hongxiang Wu, Xuechen Li

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Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Zhenquan SunDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China.ORCID 0000-0003-0877-9015

Wai Yin YauZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, P. R. China.

Huajie KangZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, P. R. China.ORCID 0009-0006-3976-3357

Haiyan ZhouDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China.

Xin LiuSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, P. R. China.ORCID 0009-0003-4070-8337

Zhibo HanSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, P. R. China.ORCID 0009-0009-9340-9908

Hongxiang WuZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, P. R. China.ORCID 0009-0009-1437-7689

Xuechen LiDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China.ORCID 0000-0001-5465-7727

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical protein synthesis has transformed the preparation of homogeneous peptides and proteins with site-specific modifications. Serine/threonine ligation offers a practical route to access difficult peptides and proteins via its aggregation-breaking intermediate, yet the preparation and regeneration of the prerequisite peptidyl salicylaldehyde ester still require the development of more efficient chemistry. Here, we report a silver(I)-mediated amide-to-ester transformation on unprotected peptides, enabled by an easily introduced

Indexed as

AmidesEstersPeptidesProtein EngineeringSilverHistonesAmidesEstersHistonesPeptidesSilver

Identifiers

PMID42814821

DOI10.1126/sciadv.aej5227

PMCPMC13626038

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