Evidence map›Paper›PMID 42814818›Full record

ArticleScience advances2026

Electronic profiling of neuronal extracellular vesicles enables early prediction of Parkinson's disease.

Tianrui Chang, Cheng Jiang, Shijun Yan, Shofarul Wustoni, Luca Salvigni, Rania Almaghrabi, Michele T Hu, George K Tofaris, Keying Guo, Sahika Inal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tianrui ChangOrganic Bioelectronics Laboratory, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.ORCID 0009-0002-6614-1538
Cheng JiangNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0003-4386-0740
Shijun YanNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0009-0007-4933-4238
Shofarul WustoniOrganic Bioelectronics Laboratory, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.ORCID 0000-0002-3059-4503
Luca SalvigniOrganic Bioelectronics Laboratory, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.ORCID 0009-0002-7484-1120
Rania AlmaghrabiOrganic Bioelectronics Laboratory, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.ORCID 0000-0003-2180-5441
Michele T HuNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0001-6382-5841
George K TofarisNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0002-9252-5933
Keying GuoOrganic Bioelectronics Laboratory, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.ORCID 0000-0001-6383-6321
Sahika InalOrganic Bioelectronics Laboratory, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.ORCID 0000-0002-1166-1512

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Misfolded alpha-Synuclein (α-Syn) accumulation is the defining molecular pathology of Parkinson's disease (PD), yet blood-based assays remain challenged by the high background of peripheral α-Syn originating mainly from red blood cells. Neuronal extracellular vesicles (EVs) circulating in blood offer a biologically enriched source of brain-derived α-Syn proteoforms, but their ultralow abundance has hindered reliable detection. Here, we introduce an organic electrochemical transistor-based multiparametric diagnostic assay that simultaneously detects total, aggregated, and serine-129-phosphorylated α-Syn proteoforms in serum L1CAM

Indexed as

alpha-SynucleinExtracellular VesiclesNeuronsParkinson DiseaseBiomarkersElectrochemical TechniquesHumansalpha-SynucleinBiomarkers

Identifiers

PMID42814818
PMCPMC13626060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.