Evidence map›Paper›PMID 42814817›Full record

ArticleScience advances2026

Predicting and finding geroprotective compounds through modulating conserved longevity-associated aging modules.

Weihan Huai, Li-Fang Ng, Jasinda H Lee, Qingyun Wang, Kamil Pabis, Zhuangli Yee, Shivaanisha Raventhiran, Shou-Ping Guan, Shermaine Thein, Stephen Dinesh Raj and 9 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Weihan HuaiDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.ORCID 0009-0003-8565-8249
Li-Fang NgDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.ORCID 0000-0002-0792-6864
Jasinda H LeeHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore.ORCID 0000-0001-7779-8135
Qingyun WangDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.ORCID 0000-0002-9765-2544
Kamil PabisDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Zhuangli YeeDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.ORCID 0000-0002-0257-5364
Shivaanisha RaventhiranHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore.ORCID 0009-0006-4046-1487
Shou-Ping GuanDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Shermaine TheinDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Stephen Dinesh RajDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.ORCID 0000-0003-2927-5000
Jerald TanDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.ORCID 0000-0002-3462-3455
Angelica Faye GaDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Sharah Mae CapinpinHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore.ORCID 0000-0001-6759-1712
Diogo BarardoDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.ORCID 0000-0001-6177-0728
Qing ZhangDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.ORCID 0009-0005-3509-8196
Zongmin LiuDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.ORCID 0000-0002-5871-5434
Esther WongHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore.ORCID 0000-0003-2421-7346
Brian Keith KennedyDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.ORCID 0000-0002-5754-1874
Jan GruberDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.ORCID 0000-0003-3329-3789

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, no generalizable tools exist for predicting the impact of interventions on aging using gene expression changes. Here, we build a model for predicting potential geroprotectors by deconstructing the aging transcriptome into coexpression modules and identifying those modulated by life span-extending interventions in

Indexed as

AgingCaenorhabditis elegansLongevityProtective AgentsAnimalsGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksMiceTranscriptomeProtective Agents

Identifiers

PMID42814817
PMCPMC13626045

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.