Evidence map›Paper›PMID 42814708›Full record

ArticlePloS one2026

OphthoEvidence report: Baseline structural optical coherence tomography biomarkers as predictors of visual outcomes following full-thickness macular hole surgery: A systematic review and meta-analysis protocol.

Sahar Khademioore, João Pedro Lima, Dena Zeraatkar, Sadia Mahmood, Sara Khademioureh, Charles C Wykoff, Peter K Kaiser, Tien-Yin Wong, Jiayuan Cheng, Mengda Li and 1 more

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Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sahar KhademiooreDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID https://orcid.org/0000-0002-3025-0006
João Pedro LimaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID https://orcid.org/0000-0002-5486-7211
Dena ZeraatkarDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Sadia MahmoodDepartment of Surgery, McMaster University, Hamilton, ON, Canada.ORCID https://orcid.org/0009-0008-1033-3315
Sara KhademiourehSchool of Public Health, University of Alberta, Edmonton, Alberta, Canada.
Charles C WykoffRetina Consultants of Texas, Houston, Texas, United States of America.ORCID https://orcid.org/0000-0001-7756-5091
Peter K KaiserCole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
Tien-Yin WongBeijing Visual Science and Translational Eye Research Institute, School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China.ORCID https://orcid.org/0000-0002-8448-1264
Jiayuan ChengTsinghua Medicine, Tsinghua University, Beijing, China.
Mengda LiBeijing Visual Science and Translational Eye Research Institute, School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China.ORCID https://orcid.org/0000-0002-3107-9482
Varun ChaudharyDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID https://orcid.org/0000-0002-9988-4146

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFull-thickness macular hole (FTMH) is a vitreoretinal condition affecting the foveal center that causes central vision loss and metamorphopsia. Despite high surgical success in achieving closure, functional visual recovery remains unpredictable. Identifying reliable optical coherence tomography (OCT) biomarkers that predict postoperative outcomes could improve patient counselling and surgical decision-making.

objectiveTo systematically evaluate the predictive value of baseline structural OCT biomarkers for visual acuity (VA) outcomes at 3, 6, 12, and 24 months following FTMH surgery.

methodsWe will search PubMed, EMBASE, Cochrane Library, and Web of Science databases from inception for studies evaluating baseline OCT parameters as predictors of postoperative VA outcomes following FTMH surgery, with minimum follow-up of 3 months. Data will be synthesized using random-effects meta-analyses. The certainty of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.

conclusionsThis systematic review will synthesize current evidence on OCT biomarkers' predictive value for FTMH surgical outcomes. The findings will clarify their clinical utility and may inform individualized prognostic counselling and surgical decision-making, including which patients are most likely to benefit from surgery and which surgical techniques may be most effective given specific OCT profiles.

Indexed as

Retinal PerforationsTomography, Optical CoherenceVisual AcuityBiomarkersHumansMeta-Analysis as TopicPrognosisSystematic Reviews as TopicTreatment OutcomeBiomarkers

Identifiers

PMID42814708
PMCPMC13626361

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.