Evidence map›Paper›PMID 42814558›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

MrtR of

Irene M Stoutland, Helen E Blackwell

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Irene M StoutlandDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.
Helen E BlackwellDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0003-4261-8194

Funding

Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
Chemical Strategies to Modulate Intercellular Bacterial CommunicationR35GM131817 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Helen E. Blackwell · 2019 to 2026
$2.9M
Chemistry-Biology Interface Training ProgramT32GM152341 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Helen E. Blackwell · 2024 to 2026
$1.6M
ACQUISITION OF MASS SPECTROMETER FOR CORE FACILITYS10RR013790 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI RAINES, RONALD T · 1999 to 1999
–
HHS | NIH (NIH) R35 GM131817HHS | NIH (NIH) S10 RR13790HHS | NIH (NIH) T32 GM008505HHS | NIH (NIH) T32 GM152341NCRR NIH HHS S10 RR013790NIGMS NIH HHS R35 GM131817NIGMS NIH HHS T32 GM008505NIGMS NIH HHS T32 GM152341NSF (NSF) BIR-9512577NSF (NSF) DGE-2137424
6 · The paper itself

Abstract

Quorum sensing (QS) enables common gram-negative bacteria to coordinate collective behaviors through small molecule signals, yet how these signals tune receptor activity remains incompletely understood. Here, we define a mechanism by which ligand structure controls function in a LuxR-type QS receptor. Using structural and biochemical analyses, we investigate MrtR from

Indexed as

Bacterial ProteinsMesorhizobiumQuorum SensingRepressor ProteinsTrans-ActivatorsAcyl-ButyrolactonesLigandsModels, MolecularProtein BindingProtein MultimerizationAcyl-ButyrolactonesBacterial ProteinsLigandsLuxR autoinducer binding proteinsRepressor ProteinsTrans-Activatorsautoinducercell–cell signalingN-acyl L-homoserine lactonequorum sensingtranscription factor

Identifiers

PMID42814558
PMCPMC13643131

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.