Evidence map›Paper›PMID 42814556›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Genome stability disrupted by the circRBM39(4,5,6)-RPA2 axis represses breast tumorigenesis.

Xing Bian, Maoyi Xu, Na Li, Chuanbo Sun, Xu Liu, Yuqi Deng, Dun Liu, Guozhen Cao, Wenchu Lin, Bo Hong and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xing Bian *Department of Obstetrics and Gynecology, The First Affiliated Hospital of University of Science and Technology of China, The Ribonucleic Acid Institute, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230027, China.
Maoyi Xu *Department of Medical Oncology, The Affiliated Hospital of Jiaxing University, Jiaxing 314001, China.ORCID 0000-0001-8532-5370
Na LiDepartment of Pathology, Jiaxing Maternity and Child Health Hospital, Affiliated Women and Children's Hospital of Jiaxing University, Jiaxing Affiliated Women and Children's Hospital of Wenzhou Medical University, Jiaxing 314000, China.
Chuanbo SunCollege of Life and Health, West Anhui University, Lu'an 237012, China.
Xu LiuDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of University of Science and Technology of China, The Ribonucleic Acid Institute, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230027, China.
Yuqi DengDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of University of Science and Technology of China, The Ribonucleic Acid Institute, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230027, China.
Dun LiuDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of University of Science and Technology of China, The Ribonucleic Acid Institute, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230027, China.
Guozhen CaoInstitute of Digestive Disease, The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen and Longgang District People's Hospital of Shenzhen, Shenzhen 518172, China.ORCID 0000-0002-0213-7153
Wenchu LinInstitute of Digestive Disease, The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen and Longgang District People's Hospital of Shenzhen, Shenzhen 518172, China.
Bo HongHefei Cancer Hospital of Chinese Academy of Sciences, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China.ORCID 0000-0001-8117-5029
Ge ShanDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of University of Science and Technology of China, The Ribonucleic Acid Institute, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230027, China.ORCID 0000-0002-3561-2088
Xiaolin WangDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of University of Science and Technology of China, The Ribonucleic Acid Institute, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230027, China.ORCID 0000-0001-9171-4073

Funding

MOST | National Natural Science Foundation of China (NSFC) 32470596
6 · The paper itself

Abstract

Genome instability (GI) is a hallmark of cancer. GI is associated with accumulative DNA damage and tumor-specific defects in DNA repair. Multiple antitumor drugs have been developed to promote persistent GI and to drive DNA damage beyond a threshold that tumor cells can survive. However, regulatory roles of circular RNAs (circRNAs) in GI and DNA damage remain elusive. Through circRNA profiling and a small interfering RNA (siRNA)-mediated screen, we have identified a circRNA termed

Indexed as

Breast NeoplasmsCarcinogenesisGenomic InstabilityReplication Protein ARNA, CircularAnimalsCell Line, TumorDNA DamageDNA RepairFemaleGene Expression Regulation, NeoplasticHumansMicePoly(ADP-ribose) Polymerase InhibitorsPoly(ADP-ribose) Polymerase InhibitorsReplication Protein ARNA, CircularRPA2 protein, humanbreast cancercircRBM39(4,5,6)genome instabilityPARP inhibitionRPA2

Identifiers

PMID42814556
PMCPMC13643296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.