Evidence map›Paper›PMID 42814518›Full record

ArticleChemistry & biodiversity2026

Seasonal and Regional Variation of the Chemical Composition and Antimicrobial Activity of Essential Oils From Piper marginatum Jacq.

Rebeca Gabriel de Camargo, Marta Cristina Teixeira Duarte, Diones Krinski, Ana Paula Palaro Klein Hendges, Aurea Portes Ferriani, Francisco de Assis Marques, Thalita Gilda Santos, Beatriz Helena Lameiro de Noronha Sales Maia

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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rebeca Gabriel de CamargoDepartamento De Química, Centro Politécnico, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0002-5535-5509
Marta Cristina Teixeira DuarteCentro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA 11), Universidade Estadual de Campinas, Paulínia, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7604-629X
Diones KrinskiCurso de Ciências Biológicas, Universidade Do Estado Do Mato Grosso, Tangará da Serra, Mato Grosso, Brazil.ORCID https://orcid.org/0000-0002-4719-5314
Ana Paula Palaro Klein HendgesUniversidade Tecnológica Federal Do Paraná, Pato Branco, Paraná, Brazil.ORCID https://orcid.org/0000-0001-5962-6399
Aurea Portes FerrianiDepartamento De Química, Centro Politécnico, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Francisco de Assis MarquesDepartamento De Química, Centro Politécnico, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Thalita Gilda SantosDepartamento De Farmácia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Beatriz Helena Lameiro de Noronha Sales MaiaDepartamento De Química, Centro Politécnico, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0001-5896-2892

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 134535/2016-2
6 · The paper itself

Abstract

Essential oils (EO) from Piper marginatum Jacq. exhibit biological activities dependent on chemical compositions, which vary mainly due to environmental factors. This study investigated the seasonal and regional variation in the chemical composition and antimicrobial activity of EO from P. marginatum leaves collected in three Brazilian regions across four seasons. Sixty compounds were identified, primarily terpenoids and phenylpropanoids. Multivariate analyses revealed seasonal variations and distinguished the Northeast region EO, which contained the isomers pipermargine (3.38%-14.56%) and 1,3,5-trimethoxy-2-[(Z)-prop-1-enyl]benzene (13.47%-14.87%)-reported for the first time in EO. The Central-West winter EO exhibited the broadest antimicrobial spectrum, with strong activity against Candida albicans (MIC 0.5 mg mL

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsOils, VolatilePiperSeasonsBacillus subtilisBrazilCandida albicansEscherichia coliMicrobial Sensitivity TestsPlant LeavesStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsOils, Volatileantimicrobial activityessential oilgas chromatographymultivariate analysisnatural products

Identifiers

PMID42814518
PMCPMC13626260

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.