ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Immunomagnetic-MXene Bifunctional Probes for Ultrasensitive and Specific Terahertz Metasensing of Tumor-Derived Exosomes.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Tumor-derived exosomes (tExos) are promising biomarkers for early pancreatic cancer (PC) diagnosis, yet current detection methods are limited by cumbersome implementation, high sample consumption, and complex matrix interference. Herein, we developed immunomagnetic-MXene bifunctional probes coupled with terahertz (THz) metamaterials to synergistically increase the sensitivity and specificity of PC-derived tExos detection. Antibodies against ZIP4 and glypican-1 (GPC-1) were separately conjugated to magnetic beads (MBs) and MXene nanosheets, which yielded two probes that simultaneously targeted PC-derived tExos, enabling highly specific sandwich-type capture of target exosomes. Moreover, MXene increased the tExo-induced THz metamaterial resonance and outperformed AuNPs in signal amplification, endowing the method with a limit of detection (LOD) of 647 particles mL
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