Evidence map›Paper›PMID 42814413›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

scH16S-Seq Maps Klebsiella pneumoniae-Associated Myeloid States and Reveals a CD38-NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis.

Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou and 6 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yangguang Li *Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People's Republic of China.ORCID https://orcid.org/0000-0002-2453-6083
Yilong Yu *Department of General Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Fang Qin *Singleron Biotechnologies, Nanjing, Jiangsu, People's Republic of China.
Shenxing Li *Research Institute of General Surgery, Jinling Hospital, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Xuanheng LiResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People's Republic of China.
Peizhao LiuResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People's Republic of China.
Juanhan LiuResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People's Republic of China.
Haiqing LiuDepartment of General Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Songqi JingResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People's Republic of China.
Jianghao ZouResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People's Republic of China.
Sicheng LiResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People's Republic of China.ORCID https://orcid.org/0009-0008-7428-8867
Jiayang LiResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People's Republic of China.
Tao ZhengDepartment of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0003-0035-7109
Yun ZhaoDepartment of General Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, People's Republic of China.ORCID https://orcid.org/0000-0001-6109-4520
Jianan RenResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People's Republic of China.ORCID https://orcid.org/0000-0002-4697-4762
Xiuwen WuResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People's Republic of China.ORCID https://orcid.org/0000-0002-3813-3867

Funding

Jiangsu Provincial Medical Innovation Center CXZX202217National Natural Science Foundation of China 82430083Scientific Research Innovation Project of Jinling Hospital 2023JSYXMS153
6 · The paper itself

Abstract

Sepsis arises from heterogeneous host-cell states that influence bacterial clearance, yet single-cell transcriptomic approaches do not directly connect microbial signals with host transcriptional programs. This study introduces single-cell host-bacterial 16S co-sequencing (scH16S-seq), which couples host transcriptomes with barcode-resolved bacterial 16S-derived UMI signals to resolve bacterial signal-enriched host-cell states. Applied to Klebsiella pneumoniae (KP) sepsis, scH16S-seq mapped cell-associated bacterial 16S-derived signals to discrete CD38

Indexed as

CD38Klebsiella pneumoniaenicotinamidescH16S‐seqsepsis

Identifiers

PMID42814413
PMCPMC13626163

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.