Evidence map›Paper›PMID 42814326›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2027

Flow Cytometric Immunophenotyping of Acute Lymphoblastic Leukemia.

Dana Delgado, Jolene L Cardinali, Joseph A DiGiuseppe

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dana DelgadoFlow Cytometry Unit, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Jolene L CardinaliDepartment of Pathology & Laboratory Medicine, Hartford Hospital, 80 Seymour St., Hartford, CT, 06102-5037, USA.
Joseph A DiGiuseppeDepartment of Pathology & Laboratory Medicine, Hartford Hospital, 80 Seymour St., Hartford, CT, 06102-5037, USA. joseph.digiuseppe@hhchealth.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunophenotyping by flow cytometry is an important component in the diagnostic evaluation of patients with acute lymphoblastic leukemia. This technique further permits the detection of minimal residual disease after therapy, a robust prognostic factor that may guide individualized treatment. We describe here laboratory methods for both the initial characterization of lymphoblasts at diagnosis and the detection of rare leukemic lymphoblasts after treatment. In addition to antibody combinations suitable for diagnosis and detection of minimal residual disease, we describe procedures for peripheral blood and bone marrow sample preparation, procedures for labeling of cell-surface and intracellular proteins with fluorochrome-conjugated antibodies, and approaches to analysis of immunophenotypic data, including those obtained in patients following CD19-targeted therapies.

Indexed as

Flow CytometryImmunophenotypingPrecursor Cell Lymphoblastic Leukemia-LymphomaHumansNeoplasm, ResidualAcute lymphoblastic leukemiaAntibodiesFlow cytometryImmunophenotypingMinimal residual diseaseTargeted therapy

Identifiers

PMID42814326

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.