ArticleDiscover nano2026
Copper bionanocomposite mitigates arsenic toxicity in Oreochromis niloticus.
Article in Discover nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
backgroundArsenic (As) is an extremely hazardous trace metalloid frequently found in water bodies, where it poses substantial threats to all living organisms, including fish. Its removal has therefore become a significant global challenge.
methodsWe explored the adsorptive capacity of a copper 1,4-benzenedicarboxylate metal-organic framework supported on rice husk-derived activated carbon (Cu-BDC@AC) nanocomposite toward As toxicity in Oreochromis niloticus. Fish were exposed to As (5 mg/L), the nanocomposite (NP, 1 mg/L), or both (As + NP) via water for 3 weeks. Serum biochemical parameters; antioxidant, pro-inflammatory, and apoptotic gene expression; hepatic and renal histopathology; and hepatic As bioaccumulation were assessed.
resultsFish exposed to As exhibited significantly higher ALT and AST activities, accompanied by pronounced oxidative stress with elevated MDA and NO levels, and depleted CAT activity and GSH concentration. Nrf-2, SOD, and CAT were significantly downregulated. It also induced inflammatory and apoptotic responses, indicated by upregulated TNF-α, IL-1β, IL-6, IL-21, IFN-γ, and caspase-3, with downregulated Bcl2 expression relative to controls. Histopathology revealed extensive hepatic and renal lesions in the As group, whereas the NP-only group showed no adverse alterations relative to controls.
conclusionsCu-BDC@AC significantly attenuated oxidative, inflammatory, and apoptotic stresses and reduced hepatic As accumulation relative to the As-intoxicated group. These findings suggest that Cu-BDC@AC can mitigate As-induced toxicity in Nile tilapia and warrant further study as a candidate bio-adsorptive material for aquaculture water treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.