Evidence map›Paper›PMID 42814153›Full record

ArticleNano convergence2026

Amplification-free colorimetric detection of exosomal miRNA using a CRISPR/Cas13a-activated HRP/Au/MoS

Myeong-Jun Lee, Minkyu Shin, Joungpyo Lim, Ha Rim Ahn, Dain Jung, Shan Liu, Chenzhong Li, Jin-Ha Choi, Jeong-Woo Choi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano convergence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Myeong-Jun Lee *Department of Chemical & Biomolecular Engineering, Sogang University, 35, Baekbeom-ro, Mapo-gu, Seoul, 04107, Republic of Korea.
Minkyu Shin *Department of Chemical Engineering, Research Center of Chemical Technology, Hankyong National University, Gyeonggi-do, 17579, Republic of Korea.
Joungpyo LimDepartment of Chemical & Biomolecular Engineering, Sogang University, 35, Baekbeom-ro, Mapo-gu, Seoul, 04107, Republic of Korea.
Ha Rim AhnDepartment of Surgery, Jeonbuk National University Medical School, Jeonju-si, 54907, Republic of Korea.
Dain JungDepartment of Chemical & Biomolecular Engineering, Sogang University, 35, Baekbeom-ro, Mapo-gu, Seoul, 04107, Republic of Korea.
Shan LiuSichuan Provincial Key Laboratory for Human Disease Gene Study, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial, People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Chenzhong LiBiomedical Engineering, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 518172, China.
Jin-Ha ChoiSchool of Chemical Engineering, Jeonbuk National University, 567, Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896, Republic of Korea. jhchoi@jbnu.ac.kr.
Jeong-Woo ChoiDepartment of Chemical & Biomolecular Engineering, Sogang University, 35, Baekbeom-ro, Mapo-gu, Seoul, 04107, Republic of Korea. jwchoi@sogang.ac.kr.ORCID http://orcid.org/0000-0003-0100-0582

Funding

HYUNSONG Educational & Cultural Foundation HYUNSONG Educational & Cultural FoundationNational Research Foundation of Korea (NRF) RS-2024-00344633National Research Foundation of Korea (NRF) RS-2026-25509643
6 · The paper itself

Abstract

CRISPR-based, amplification-free colorimetric sensing has emerged as a powerful approach for exosomal miRNA (Exo-miR) analysis, offering high specificity, simple operation, and direct visual readout suitable for point-of-care diagnostics. However, the sensitivity of existing systems is limited because conventional colorimetric probes generate inherently weak signals, making the reliable detection of ultralow-abundance Exo-miRs difficult without amplification. Here, we firstly report an amplification-free colorimetric biosensor based on a horseradish peroxidase (HRP)/gold nanoparticle (Au)/molybdenum disulfide (MoS

Indexed as

Breast cancerColorimetric biosensorCRISPR/Cas13aExosomal miRNANanobiohybrid catalyst

Identifiers

PMID42814153
PMCPMC13627550

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.