Evidence map›Paper›PMID 42814027›Full record

ArticleJournal of human immunity2026

Life-threatening hepatic complications in children with ADA-SCID.

Ridhima Aggarwal, Alison Mansfield, Jinhua Xu-Bayford, Claire Booth, Konstantinos Vazouras

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ridhima AggarwalUniversity College London Great Ormond Street Institute of Child Health , London, UK.ORCID 0000-0003-4949-5166
Alison MansfieldUniversity College London Great Ormond Street Institute of Child Health , London, UK.ORCID 0009-0005-9575-735X
Jinhua Xu-BayfordUniversity College London Great Ormond Street Institute of Child Health , London, UK.ORCID 0009-0001-9977-3147
Claire BoothUniversity College London Great Ormond Street Institute of Child Health , London, UK.ORCID 0000-0002-2626-5037
Konstantinos VazourasUniversity College London Great Ormond Street Institute of Child Health , London, UK.ORCID 0000-0002-5278-0083

Funding

European Society for ImmunodeficienciesGreat Ormond Street Hospital National Institute for Health and Care Research Biomedical Research Centre
6 · The paper itself

Abstract

We describe two cases of ADA-SCID complicated by hepatoblastoma and infantile hepatic hemangiomatosis. We highlight the multidisciplinary management of these severe liver manifestations and the modifications required to deliver definitive corrective therapy, including gene therapy and hematopoietic stem cell transplantation.

Identifiers

PMID42814027
PMCPMC13625848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.