Evidence map›Paper›PMID 42813934›Full record

ArticleTranslational vision science & technology2026

Noninterchangeability of Vessel Density Measurements Across Next-Generation SS-OCTA Systems.

Peter M Maloca, Philippe C Cattin, Nadja Inglin, Claudia Bruè, Pascal W Hasler, Simon Rothenbuehler, Hanna Zuche, Javier Zarranz-Ventura, Philippe Valmaggia

Abstract read
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Article in Translational vision science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peter M MalocaDepartment of Biomedical Engineering, University of Basel, Allschwil, Switzerland.
Philippe C CattinDepartment of Biomedical Engineering, University of Basel, Allschwil, Switzerland.
Nadja InglinDepartment of Ophthalmology, University Hospital Basel, Basel, Switzerland.
Claudia BruèOphthalmic clinic, Macerata Hospital, Macerata, Italy.
Pascal W HaslerDepartment of Ophthalmology, University Hospital Basel, Basel, Switzerland.
Simon RothenbuehlerDepartment of Ophthalmology, University Hospital Basel, Basel, Switzerland.
Hanna ZucheDepartment of Ophthalmology, University Hospital Basel, Basel, Switzerland.
Javier Zarranz-VenturaInstitut Clínic de Oftalmologia (ICOF), Hospital Clínic de Barcelona, Barcelona, Spain.
Philippe ValmaggiaDepartment of Biomedical Engineering, University of Basel, Allschwil, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Comparing swept-source optical coherence tomography angiography (OCTA) vessel density in the superficial and deep capillary plexuses across leading OCTA systems. Methods: OCTAs were acquired from healthy participants using two OCTA systems (BMizar 400 kHz and Yalkaid 100 kHz, TowardPi, Beijing, China) with scan sizes of 3 × 3, 6 × 6, 12 × 12, and 15 × 15 mm2. The vessel density was quantified using the manufacturer's software. Results: Across 30 subjects comprising 60 eyes and a total of 225 OCTA scans, significant interdevice differences were observed at the Early Treatment Diabetic Retinopathy Study sector level in all eight scan size × plexus comparisons (three-way analysis of variance; P < 1.16 × 10e-4). The mean BMizar vessel density values for the superficial and deep plexuses were 43.4% ± 1.6% and 44.9% ± 1.5%, 44.7% ± 2.7% and 47.9% ± 1.1%, 44.2% ± 1.3% and 45.7% ± 1.1%, and 42.4 ± 1.6 % and 44.3 ± 1.3% for the 3 × 3, 6 × 6, 12 × 12, and 15 × 15 mm² scans; the Yalkaid values were lower. BMizar showed greater vessel density than Yalkaid, particularly in 3 × 3 mm² deep slab scans, with differences of approximately 5% to 10%. Across scans larger than 3 × 3 mm², BMizar showed greater central vessel density; the peripheral patterns varied, with reversals favoring Yalkaid and greater border effects in larger fields of view. Conclusions: Despite interdevice differences, both devices showed consistent OCTA acquisition. Translational Relevance: Device differences may affect clinical interpretation, longitudinal follow-up, and multicenter studies.

Indexed as

Fluorescein AngiographyRetinal VesselsTomography, Optical CoherenceAdultFemaleHumansMaleMiddle Aged

Identifiers

PMID42813934
PMCPMC13641204

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.