Trial reportPulmonary medicine2026
Quantification of Immediate Surgical Stress After Major and Minor Thoracic Surgeries Through HRV: A Secondary Post Hoc Analysis of a Randomized Controlled Trial.
Trial report in Pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02931617 (Comparison of Two Modes of Respiratory Physiotherapy in Cardio-thoracic Surgical Patients), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Two Modes of Respiratory Physiotherapy in Cardio-thoracic Surgical Patients
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeHeart rate variability (HRV) reflects autonomic nervous system activity and is sensitive to physiological stress induced by surgery. This study is a secondary, post hoc analysis of a randomized controlled trial aimed at evaluating changes in HRV following major and minor thoracic surgery, and investigating whether postoperative respiratory physiotherapy can modulate these changes. In a prospective, randomized design, two physiotherapy interventions, including positive expiratory pressure (PEP) and inspiratory muscle training (IMT), were compared to assess their effects on HRV.
methodsElectrocardiogram recordings were analyzed from 75 patients undergoing either minor pulmonary (PM) or pulmonary resection (PR) surgery. HRV data were collected preoperatively and during the first two postoperative days, immediately following physiotherapy sessions. Patients were assigned to one of two intervention groups (PEP or IMT). Time-, frequency-, and nonlinear-domain HRV parameters were analyzed longitudinally and compared between surgical and intervention groups.
resultsMost HRV parameters exhibited a postoperative reduction, with more pronounced changes observed in the PR surgery group. In particular, the root mean square of successive RR interval differences (RMSSD) and high-frequency (HF) power, which are commonly associated with parasympathetic modulation, showed marked decreases. Recovery toward baseline values varied across surgical groups, interventions, and HRV parameters; however, no clear signs of recovery were observed in the PR surgery group during the observation period. No statistically significant differences were detected between the PEP and IMT interventions (p ≥ 0.05), with the exception of short-term detrended fluctuation analysis (DFA α
conclusionHRV parameters reflected surgery-induced autonomic alterations, with more pronounced and persistent changes observed in patients undergoing PR compared with PM surgery. No clear recovery toward baseline was detected during the 2-day postoperative follow-up, suggesting prolonged autonomic disturbances after thoracic surgery.
trial registrationClinicalTrials.gov: NCT02931617.
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