Evidence map›Paper›PMID 42813829›Full record

ArticleDevelopmental psychobiology2026

Maternal Depression, Childhood Resting-State Brain Connectivity, and Adolescent Depression During the COVID-19 Outbreak.

Pan Liu, Matthew R J Vandermeer, Andrew R Daoust, Haley E Green, Ola Mohamed Ali, Kasey Stanton, Kate L Harkness, Deanna M Barch, Marc F Joanisse, Elizabeth P Hayden

Abstract read
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In one paragraph

Article in Developmental psychobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pan LiuDepartment of Psychology, Brain & Mind Institute, Western University, London, Ontario, Canada.
Matthew R J VandermeerDepartment of Psychology, Brain & Mind Institute, Western University, London, Ontario, Canada.
Andrew R DaoustDepartment of Psychology, Brain & Mind Institute, Western University, London, Ontario, Canada.
Haley E GreenDepartment of Psychology, Brain & Mind Institute, Western University, London, Ontario, Canada.
Ola Mohamed AliDepartment of Psychology, Brain & Mind Institute, Western University, London, Ontario, Canada.
Kasey StantonDepartment of Psychology, University of Wyoming, Laramie, Wyoming, USA.
Kate L HarknessDepartment of Psychology, Queen's University, Kingston, Ontario, Canada.
Deanna M BarchDepartment of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, Missouri, USA.
Marc F JoanisseDepartment of Psychology, Brain & Mind Institute, Western University, London, Ontario, Canada.
Elizabeth P HaydenDepartment of Psychology, Brain & Mind Institute, Western University, London, Ontario, Canada.

Funding

Canada First Research Excellence FundCIHR MOP86458Ontario Mental Health FoundationSocial Sciences and Humanities Research Council Insight Grant
6 · The paper itself

Abstract

Adolescents of mothers with a history of depression are at increased risk for developing depression themselves. These adolescents may have been especially vulnerable to depression under conditions of stress, such as the beginning of the COVID-19 pandemic. To understand the complex processes involved in the transmission of maternal depression risk to adolescent offspring in the context of stress, we examined potential mediating and moderating factors that link maternal depression history and offspring depressive symptoms, including resting-state functional connectivity (rs-FC) and mothers' depressive symptoms, in 85 adolescents during the pandemic. Adolescents' prepandemic rs-FC between the posterior and anterior cingulate cortices (PCC-ACC) moderated the association between maternal depression history and adolescents' symptoms during the pandemic, such that maternal depression history predicted adolescents' symptoms only in youths with heightened PCC-ACC rs-FC. Mothers' depressive symptoms during the pandemic mediated and moderated the link between maternal depression history and adolescents' symptoms. Mothers with a history of depression had greater depressive symptoms early during the pandemic, which were further associated with offspring depressive symptoms. Additionally, maternal depression history predicted depressive symptoms in adolescents whose mothers had lower depressive symptoms during the pandemic. Findings speak to the mediating and moderating processes in the transmission of maternal depression risk to adolescent offspring in the context of the pandemic.

Indexed as

Child of Impaired ParentsConnectomeCOVID-19DepressionGyrus CinguliMothersAdolescentFemaleHumansMagnetic Resonance Imagingadolescencecortical midline structureCOVID‐19maternal depressionresting‐state functional connectivity

Identifiers

PMID42813829
PMCPMC13625808

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.