ArticleHypertension (Dallas, Tex. : 1979)2026
Frailty Index Progression Around Hypertension Diagnosis in 14 Countries.
Article in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertension and frailty frequently coexist in older adults. However, relationships between their trajectories are unclear. This study aims to examine whether frailty progressed differently between individuals with and without hypertension before and after diagnosis.
methodsData were drawn from 3 nationally representative cohorts across 14 countries, including 21 418 participants (mean baseline age 63.2±10.2 years) followed for 16 to 18 years. Individuals with hypertension at baseline were excluded. Hypertension was defined by self-reported physician diagnosis and antihypertensive medication use by self-report of taking any medication. Diagnosis timing was based on the first survey wave at which hypertension was reported. Coarsened exact matching matched participants who developed hypertension with those who did not. Piecewise linear mixed models estimated frailty trajectories before and after diagnosis.
resultsAmong 10 709 participants who developed hypertension (median diagnosis age 70 years), frailty index rescaled to a 0 to 100 scale (0-100) increased by 0.63 points/y (95% CI, 0.57-0.70) before diagnosis and 1.09 points/y (95% CI, 0.97-1.21) after diagnosis. During the 8 years preceding diagnosis, participants who developed hypertension experienced greater increases in frailty index rescaled to a 0 to 100 scale than matched controls without hypertension (difference, 2.69 [95% CI, 2.43-2.95]). The corresponding difference during the 8 years after diagnosis was 1.51 (95% CI, 1.01-2.01). Among individuals with hypertension, antihypertensive medication use was associated with a nonsignificant reduction in frailty progression after diagnosis. Findings remained robust after excluding participants with cardiovascular conditions.
conclusionsParticipants with hypertension experienced faster frailty progression before and after diagnosis. Studies using objective blood pressure measurement are needed to confirm this association.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.