Evidence map›Paper›PMID 42813233›Full record

ArticleDisease models & mechanisms2026

Sex-dependent mild cardiac dysfunction and neurometabolic abnormalities in a model of Huntington's disease.

Kenna L R Hynes, Thomas M O'Brien, Jenna Hanrahan, Rachel Neita, T Nadine Burry, Michael R Hayden, Matthew P Parsons, Amber L Southwell, Lindsay S Cahill

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kenna L R HynesDepartment of Chemistry, Memorial University of Newfoundland, St John's, NL A1C 5S7, Canada.
Thomas M O'BrienDepartment of Chemistry, Memorial University of Newfoundland, St John's, NL A1C 5S7, Canada.
Jenna HanrahanDepartment of Chemistry, Memorial University of Newfoundland, St John's, NL A1C 5S7, Canada.
Rachel NeitaDepartment of Chemistry, Memorial University of Newfoundland, St John's, NL A1C 5S7, Canada.
T Nadine BurryDepartment of Chemistry, Memorial University of Newfoundland, St John's, NL A1C 5S7, Canada.
Michael R HaydenCentre for Molecular Medicine and Therapeutics, Vancouver, BC V5Z 4H4, Canada.
Matthew P ParsonsFaculty of Medicine, Division of Biomedical Sciences, Memorial University of Newfoundland, St John's, NL A1B 3X7, Canada.
Amber L SouthwellBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USA.
Lindsay S CahillDepartment of Chemistry, Memorial University of Newfoundland, St John's, NL A1C 5S7, Canada.ORCID 0000-0003-1667-8564

Funding

Brain CanadaCanada Foundation for InnovationMemorial University of NewfoundlandNatural Sciences and Engineering Research Council of CanadaNewfoundland and Labrador Department of Industry, Energy and Technology
6 · The paper itself

Abstract

Huntington's disease (HD) is a neurodegenerative disease with progressive decline in psychiatric, motor and cognitive symptoms. Hallmarks of HD include brain volume loss and abnormal metabolism. However, HD is a multi-system disorder, and the impact on other organ systems is poorly understood. Using high-frequency ultrasound and nuclear magnetic resonance, we studied cardiac function (n=9-11 mice/genotype/sex) and brain metabolism (n=10 mice/genotype/sex) in a humanized transgenic mouse model of HD (Hu97/18 mice) at 12 months of age. The assessments were conducted in different cohorts and analyzed separately. Compared to controls (Hu18/18 mice), Hu97/18 mice showed a decrease in the left ventricle ejection fraction in both sexes and an increase in the E/A ratio (E wave/A wave diastolic filling) in females, indicative of mild cardiac dysfunction. The relative concentrations of several metabolites in the brain were altered in Hu97/18 mice, compared to those in Hu18/18 mice, and depended on sex and brain region. These findings are consistent with clinical features observed in human HD, supporting use of the Hu97/18 model for investigation of pathophysiology in HD in multiple organ systems. It also highlights the importance of studying both sexes in HD research.

Indexed as

Huntington DiseaseSex CharacteristicsAnimalsBrainDisease Models, AnimalFemaleHumansMaleMiceMice, TransgenicBrain metabolismCardiac functionHuntington's diseaseMouseSex differences

Identifiers

PMID42813233
PMCPMC13670356

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.