ArticleCureus2026
Retrograde Cerebral Perfusion in Type A Aortic Dissection Repair Is Associated With Higher Rates of Postoperative Complications.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The comparative short- and long-term outcomes of retrograde versus antegrade cerebral perfusion during circulatory arrest for acute type A aortic dissection repair remain debated. Methods In this single-center retrospective study, postoperative outcomes were compared between retrograde and antegrade cerebral perfusion. Retrograde cerebral perfusion was employed in older patients (median age = 72 vs. 63 years; p = 0.030), with comparable body mass index (29 vs. 28 kg/m²; p = 0.649). Results Relative to antegrade cerebral perfusion, retrograde cerebral perfusion was associated with increased 30-day mortality (40% vs. 13%; p = 0.003), postoperative pericardial and pleural effusion (75% vs. 43%; p = 0.009), and cerebrovascular accident (35% vs. 16%; p = 0.044). After multivariable adjustment for circulatory arrest time and nadir hypothermic temperature, retrograde perfusion independently predicted 30-day mortality (adjusted odds ratio: 7.66; 95% CI: 2.16-27.13; p = 0.002). Conclusions These findings suggest that retrograde cerebral perfusion is associated with worse postoperative outcomes following acute type A aortic dissection repair and warrant further investigation.
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