ReviewCureus2026
Lifestyle Medicine and the Science of Cholesterol Reduction: A Systematic Review of Non-medication Approaches Among Adults.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dyslipidemia is a major modifiable risk factor for cardiovascular disease and remains highly prevalent despite advances in lipid-lowering therapy. Lifestyle medicine has emerged as a comprehensive, non-pharmacological strategy for improving lipid profiles and reducing cardiovascular risk. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines and evaluated the effectiveness of lifestyle-based interventions for cholesterol reduction in adults. PubMed, Scopus, Web of Science, Embase, and the Cochrane Library were searched for observational studies published between 2015 and May 2026. Studies involving adults (≥18 years) that evaluated lifestyle interventions and reported lipid-related outcomes were included. Study quality was assessed using the Newcastle-Ottawa Scale. Twenty-six studies met the inclusion criteria. Mediterranean and plant-based diets, together with regular physical activity, were consistently associated with reductions in low-density lipoprotein cholesterol and triglycerides, improvements in high-density lipoprotein cholesterol, and lower cardiovascular risk. Weight management, smoking cessation, adequate sleep, and stress reduction were also associated with favorable lipid outcomes. However, long-term adherence was frequently limited by socioeconomic and behavioral barriers. Lifestyle medicine provides an important foundation for dyslipidemia management and should be integrated with pharmacological therapy when clinically indicated. Future research should focus on improving long-term adherence and equitable access to lifestyle-based interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.