Evidence map›Paper›PMID 42813043›Full record

ArticleJournal of biomedical optics2026

Quantitative optical property mapping of the periocular region using spatial frequency domain imaging.

Lilangi S Ediriwickrema, Miranda B An, Stephanie D Kirk, John Abdelmalek, Divya Devineni, Shijun Sung, Katherine Chen, Kaylyn C Mattick, Fiza A Qureshi, Claire Malley and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lilangi S EdiriwickremaUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Miranda B AnUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Stephanie D KirkUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
John AbdelmalekUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Divya DevineniUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Shijun SungUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Katherine ChenUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Kaylyn C MattickUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Fiza A QureshiUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Claire MalleyUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Jaylen M LeeUniversity of California, Biostatistics, Epidemiology, and Research Design Unit, Irvine, California, United States.ORCID https://orcid.org/0009-0009-8020-3492
Danny XieUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Gordon T KennedyUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.ORCID https://orcid.org/0000-0002-2335-8887
Bernard ChoiUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.ORCID https://orcid.org/0000-0002-4380-8291
Anthony J DurkinUniversity of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.

Funding

Institutional Career Development CoreKL2TR001416 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, DEMETRIOU, MICHAEL · 2015 to 2023
$5.6M
Spatial Frequency Domain Imaging for Burn Wound Severity AssessmentR01GM108634 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY J · 2014 to 2023
$2.8M
Spatial Frequency Domain Imaging to Investigate Mechanistic Constituents in Active Thyroid Eye DiseaseK23EY036491 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Lilangi Ediriwickrema · 2025 to 2026
$516k
NCATS NIH HHS KL2 TR001416NEI NIH HHS K23 EY036491NIGMS NIH HHS R01 GM108634
6 · The paper itself

Abstract

Significance: Noninvasive characterization of periocular skin optical properties is critical for understanding tissue alterations associated with thyroid eye disease and other orbital adnexal pathologies. Spatial frequency domain imaging (SFDI) provides quantitative, Aim: The study aims to establish normative SFDI-derived optical properties of periocular skin in the absence of cutaneous disease. Approach: Twenty-five healthy participants were imaged using the Reflect RS™ SFDI system. Reduced scattering ( Results: Normative ranges for Conclusions: This study provides the first quantitative characterization of normal periocular skin using SFDI across diverse skin types. Measurements were robust to acquisition angle but varied with pigmentation, underscoring the need to account for Fitzpatrick scores in clinical applications. Establishing normative data is essential for future studies involving periocular disease.

Indexed as

Image Processing, Computer-AssistedOptical ImagingSkinAdultFemaleHumansMaleMiddle AgedReproducibility of ResultsYoung Adultoculofacialoptical propertiesorbitalperiocularspatial frequency domain imaging

Identifiers

PMID42813043
PMCPMC13621795

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.