ArticleJournal of toxicology2026
Effect of Herbal Extracts on Antituberculosis Drug-Induced Hepatotoxicity: A Systematic Review.
Article in Journal of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Background: Tuberculosis (TB) remains a major global health challenge. While effective, first-line antitubercular drugs such as isoniazid and rifampicin often cause hepatotoxicity, limiting treatment safety. Herbal extracts with antioxidant and hepatoprotective properties may help mitigate this liver damage. This systematic review evaluates the protective effects of plant extracts against antitubercular drug-induced hepatotoxicity, aiming to inform potential adjuvant strategies. Methods: Following PRISMA-P guidelines, PubMed, Scopus, and Google Scholar were searched for "in vivo studies assessing plant extracts against hepatotoxicity caused by anti-TB drugs." Two independent reviewers screened and extracted data. Study quality was evaluated using SYRCLE's risk of bias tool. Results: Sixty-eight in vivo studies were included. Overall, plant extracts demonstrated variable hepatoprotective efficacy, with some showing significant improvement in certain species- Conclusion: Medicinal plants demonstrate variable hepatoprotective effects in animal models of anti-TB drug-induced liver injury, though their mechanisms of oxidative stress remain unclear. Among them, the extracts from
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