ArticleCureus2026
Intradiscal Condoliase Injection for Lateral Lumbar Disc Herniation in a Patient Receiving Long-Term Hemodialysis: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Spine surgery in dialysis-dependent patients is challenging because of the high risk of perioperative complications. We report the case of a chronic dialysis patient with lateral lumbar disc herniation (LDH) successfully treated with intradiscal condoliase injection therapy. A 51-year-old Japanese male who had been undergoing hemodialysis for 16 years presented with severe left lower extremity pain caused by a left L5-S1 disc herniation with both foraminal and extraforaminal components. Conservative treatments were ineffective, and intradiscal condoliase injection was performed without complications. The patient's pain significantly improved within three months after the injection. An MRI performed 15 months after treatment demonstrated marked shrinkage of the herniation, and no recurrence of leg pain was observed during the 15-month follow-up period. Condoliase therapy was developed in Japan and has shown favorable outcomes for LDH; however, there have been no previous reports in dialysis-dependent patients. Intradiscal condoliase injection may be a safe and effective minimally invasive treatment option for high-risk dialysis-dependent patients with LDH.
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