Evidence map›Paper›PMID 42812754›Full record

ArticleJournal of aging research2026

The Influence of Age on Notch1 and VEGF-A Responses During Exercise.

Brooke R Shepley, Lana H Yacoub, Nicholas J Lester, Rian A Grassi, Jessica N Kenney, Kevin J Milne, Anthony R Bain

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of aging research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brooke R ShepleyDepartment of Kinesiology, Faculty of Human Kinetics, University of Windsor, Windsor, Ontario, Canada, uwindsor.ca.ORCID https://orcid.org/0009-0002-5111-3286
Lana H YacoubSchulich School of Medicine and Dentistry, Western University, London, Ontario, Canada, uwo.ca.
Nicholas J LesterDepartment of Nursing, Faculty of Nursing, University of Windsor, Windsor, Ontario, Canada, uwindsor.ca.
Rian A GrassiDepartment of Chemistry and Biochemistry, Faculty of Science, University of Windsor, Windsor, Ontario, Canada, uwindsor.ca.ORCID https://orcid.org/0009-0007-9372-0689
Jessica N KenneyDepartment of Kinesiology, Faculty of Human Kinetics, University of Windsor, Windsor, Ontario, Canada, uwindsor.ca.
Kevin J MilneDepartment of Kinesiology, Faculty of Human Kinetics, University of Windsor, Windsor, Ontario, Canada, uwindsor.ca.
Anthony R BainDepartment of Kinesiology, Faculty of Human Kinetics, University of Windsor, Windsor, Ontario, Canada, uwindsor.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Notch1 and vascular endothelial growth factor-A (VEGF-A) are polyfunctional signaling molecules that can be activated in response to elevated shear stress. In nonpathological conditions, they are integral to healthy endothelium; however, it is unknown whether their responsiveness during aerobic exercise, a robust shear stimulus, is impacted by age. Accordingly, in this exploratory cross-sectional study, concentrations of VEGF-A and Notch1 extracellular domain (NECD) were quantified in twenty-nine (13 females) healthy adults (mean age: 32 years, range: 20-65), using venous blood samples taken at rest, immediately postexercise (cycle V̇O

Identifiers

PMID42812754
PMCPMC13621830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.