Evidence map›Paper›PMID 42812741›Full record

ArticleClinical case reports2026

Scrub Typhus Meningoencephalitis With Concurrent Brucellosis in Rural Nepal: Diagnostic Challenges With Negative PCR in a Low-Resource Setting.

Pashupati Pokharel, Diwash Rai, Milan Bajracharya, Abhikshya Basnet, Bimal Sharma Chalise, Arati Baskota, Andrew B Trotter

Abstract read
In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pashupati PokharelInstitute of Medicine, Tribhuvan University Kathmandu Nepal.ORCID https://orcid.org/0000-0002-9704-5883
Diwash RaiPatan Academy of Health Sciences Lalitpur Nepal.
Milan BajracharyaSukraraj Tropical and Infectious Disease Hospital Teku, Kathmandu Nepal.ORCID https://orcid.org/0009-0000-7617-5200
Abhikshya BasnetSukraraj Tropical and Infectious Disease Hospital Teku, Kathmandu Nepal.ORCID https://orcid.org/0009-0002-1710-8926
Bimal Sharma ChaliseSukraraj Tropical and Infectious Disease Hospital Teku, Kathmandu Nepal.ORCID https://orcid.org/0000-0003-2941-8307
Arati BaskotaKathmandu Medical College and Teaching Hospital Kathmandu Nepal.ORCID https://orcid.org/0000-0001-6921-8014
Andrew B TrotterDivision of Infectious Disease, Department of Medicine University of Illinois Chicago College of Medicine Chicago Illinois USA.ORCID https://orcid.org/0000-0001-7069-2979

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scrub typhus is an important cause of acute febrile illness in Nepal and can rarely present with meningoencephalitis and multiorgan involvement. We report a 32-year-old female farmer from rural Nepal who presented during the monsoon season with high-grade fever, myalgia, vomiting, and an eschar following an unidentified forest bite. She developed meningismus, hypotension, mild acute respiratory distress syndrome, and transaminitis. Cerebrospinal fluid showed lymphocytic pleocytosis and elevated protein, while bacterial culture, acid-fast staining, and GeneXpert were negative. Serum scrub typhus IgM was positive, whereas

Indexed as

BrucellosisMeningoencephalitisOrientia tsutsugamushiPCR‐negative infectionScrub typhus

Identifiers

PMID42812741
PMCPMC13620217

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.