ArticleFrontiers in physiology2026
Spatially resolved longitudinal changes in tibial subchondral trabecular bone texture for exploratory prediction of incident knee osteoarthritis.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Although prediction of radiographic knee osteoarthritis (rKOA) using baseline clinical and radiological data has been widely studied, the impact of temporal changes in imaging and clinical biomarkers remains less investigated. This study examined whether longitudinal changes in spatially resolved trabecular bone texture (TBT) improve prediction of incident rKOA. Participants with longitudinal data were selected from the Osteoarthritis Initiative. Incident rKOA was defined as Kellgren-Lawrence grade (KL) 0 at baseline and KL ≥ 2 at 48 months. One knee per participant was included (n=481). Fractal-based TBT descriptors were extracted from 16 automatically defined regions of interest across the tibial subchondral bone. Five logistic-regression models combined baseline clinical and radiological covariates, baseline TBT, and 24-month longitudinal changes (ΔTBT). Bidirectional stepwise selection based on the Akaike Information Criterion was applied once to TBT descriptors, whereas clinical and radiological covariates were incorporated
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